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Unexpected Therapeutic Effects of Common Drugs: Lessons from 15 Years of Drug R...
Gonçalves, Jorge Manuel Moreira; Quintas, Clara; Silva, Dany; Queiroz, Glória; Fresco, PaulaDrug repurposing (DR) is one of the expressions that has been used to translate the process of discovering new therapeutic uses for drugs already approved for other clinical indications. The concept was presented 15 years ago. Initially, the intention was to shorten the pharmaceutical research and development (R&D) process and thereby reduce the costs and risks for the pharmaceutical industry to bring new m...
β-Adrenoceptor Activation in Breast MCF-10A Cells Induces a Pattern of Catechol...
Amaro, Filipa; Silva, Dany; Reguengo, Henrique; Oliveira, José Carlos; Quintas, Clara; Vale, Nuno; Gonçalves, Jorge; Fresco, PaulaAdrenaline, which participates in the neuroendocrine response that occurs during stress and perimenopause, may be tumorigenic. This exploratory study aimed at investigating whether non-tumorigenic and tumorigenic human breast epithelial cell lines are able to synthesize adrenaline. The study was carried out in non-tumorigenic (MCF-10A) and tumorigenic (MCF-7) human breast cell lines. Expression of enzymes invol...
Chronic medication in the perioperative period: usage profile and risk management.
Castanheira, Liliana; Palmeiro, Ana; Fresco, Paula; Macedo, Ana FilipaCurrently, an increasing number of surgeries are performed in an older and higher risk population, due to the inherent comorbidity and polypharmacy associated with this population group. The characterization of drug usage profiles in the perioperative period is critically needed to understand the nature of adverse events and to achieve a more efficient iatrogenic risk management.During 1 year, all adult patient...
Cytotoxic and COX-2 Inhibition Properties of Hydroxycinnamic Derivatives
Marques, M. Paula M.; Borges, Fernanda; Sousa, Joana; Calheiros, Rita; Garrido, Jorge; Gaspar, Alexandra; Diniz, Carmen; Fresco, Paula