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Induction and initial characterization of a new Helicobacter pylori prophage
Ferreira, Rute Vanessa Novais; Sousa, Cláudia Sofia Cunha; Presa, Eva; Pires, Diana Priscila Penso; Mónica Oleastro; Azeredo, Joana; Figueiredo, CéuHelicobacter pylori is a Gram-negative bacterium that colonizes the stomach and it is considered one of the major human pathogens. Current treatments include a set of antibiotics with decreasing eradication rates, mainly due to the increase in the appearance of antibiotic-resistant strains. Bacterio(phages) have emerged in recent years as an effective alternative to fight bacterial infections. For therapeutic p...
Validation of a Fluorescence In Situ Hybridization Method Using Peptide Nucleic...
Cerqueira, L.; Ricardo M. Fernandes; Rui M. Ferreira; Mónica Oleastro; Fátima Carneiro; Catarina Brandão; Pedro Pimentel Nunes; Mário Dinis RibeiroHere, we evaluated a previously established peptide nucleic acid-fluorescence in situ hybridization (PNA-FISH) method as a new diagnostic test for Helicobacter pylori clarithromycin resistance detection in paraffin-embedded gastric biopsy specimens. Both a retrospective study and a prospective cohort study were conducted to evaluate the specificity and sensitivity of a PNA-FISH method to determine H. pylori cla...