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Molecularly defined sinonasal malignancies: an overview with focus on the curre...

Skálová, Alena; Agaimy, Abbas; Bradova, Martina; Poorten, Vincent Vander; Hanna, Ehab; Guntinas-Lichius, Orlando; Franchi, Alessandro; Hellquist, Henrik

Classification of tumors of the head and neck has evolved in recent decades including a widespread application of molecular testing in tumors of the sinonasal tract, salivary glands, and soft tissues with a predilection for the head and neck. The availability of new molecular techniques has allowed for the definition of multiple novel tumor types unique to head and neck sites. Moreover, an expanding spectrum of...


An evidence-based analysis of the management of N0 neck in patients with cancer...

Vartanian, Jose Guilherme; Goncalves Filho, Joao; Kowalski, Luiz Paulo; Shah, Jatin P.; Suarez, Carlos; Rinaldo, Alessandra; De Bree, Remco

Introduction: Management of clinically negative neck (cN0) in patients with parotid gland cancer is controversial. Treatment options can include observation, elective neck dissection or elective radiotherapy. Areas covered: We addressed the treatment options for cN0 patients with parotid gland cancer. A literature review was undertaken to determine the optimal management of this group of patients. Expert opinio...


Analysis of the clinical relevance of histological classification of benign epi...

Hellquist, Henrik; Paiva-Correia, António; Poorten, Vincent Vander; Quer, Miquel; Hernandez-Prera, Juan C.; Andreasen, Simon; Zbären, Peter

IntroductionA vast increase in knowledge of numerous aspects of malignant salivary gland tumours has emerged during the last decade and, forseveral reasons, thishas not been the case in benign epithelial salivary gland tumours. We have performed a literature review to investigate whether an accurate histological diagnosis of the 11 different types of benign epithelial salivary gland tumours is correlated to any...


Newly described entities in salivary gland pathology

Skalova, Alena; Gnepp, Douglas R.; Lewis, James S., Jr.; Hunt, Jennifer L.; Bishop, Justin A.; Hellquist, Henrik; Rinaldo, Alessandra

Salivary glands may give rise to a wide spectrum of different tumors. This review concentrates on 4 salivary gland tumors that have been accepted in the recent literature as new neoplastic entities: mammary analog secretory carcinoma, cribriform adenocarcinoma of minor salivary glands (CASG), sclerosing polycystic adenosis/adenoma (SPA), and the mucinous/secretory variant of myoepithelioma. Mammary analog secre...


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