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Association Between Ventilatory Settings and Development of Acute Respiratory D...

Tejerina, E; Pelosi, P; Muriel, A; Peñuelas, O; Sutherasan, Y; Frutos-Vivar, F; Nin, N; Davies, AR; Rios, F; Violi, DA; Raymondos, K; Hurtado, J

PURPOSE: In neurologically critically ill patients with mechanical ventilation (MV), the development of acute respiratory distress syndrome (ARDS) is a major contributor to morbidity and mortality, but the role of ventilatory management has been scarcely evaluated. We evaluate the association of tidal volume, level of PEEP and driving pressure with the development of ARDS in a population of patients with brain ...


Outcome of mechanically ventilated patients who require a tracheostomy

Frutos-Vivar, F; Esteban, A; Apezteguía, C; Anzueto, A; Nightingale, P; González, M; Soto, L; Rodrigo, C; Raad, J; David, C; Matamis, D; D'Empaire, G

OBJECTIVE: To estimate the prevalence of, the risk factors associated with, and the outcome of tracheostomy in a heterogeneous population of mechanically ventilated patients. DESIGN: Prospective, observational cohort study. SETTING: A total of 361 intensive care units from 12 countries. PATIENTS: A cohort of 5,081 patients mechanically ventilated for >12 hrs. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: ...


Use of sedatives and neuromuscular blockers in a cohort of patients receiving m...

Arroliga, A; Frutos-Vivar, F; Hall, J; Esteban, A; Apezteguía, C; Soto, L; Anzueto, A; Freitas, PT; International Mechanical Ventilation Study Group.

OBJECTIVE: To describe the use of sedatives and neuromuscular blocking agents (NMBs) and their impact in outcome in an international cohort of patients receiving mechanical ventilation. METHODS: We analyzed the database of a prospective, multicenter cohort of 5,183 adult patients who received mechanical ventilation for > 12 h. We considered that a patient received a given agent when it was administered for at l...


Prognosis factors and outcome of community-acquired pneumonia needing mechanica...

Tejerina, E; Frutos-Vivar, F; Restrepo, M; Anzueto, A; Palizas, F; Gonzaléz, M; Aspesteguía, C; Abroug, F; Matanis, D; Bugedo, G; Esteban, A

PURPOSE: To evaluate the variables associated with mortality of patients with community-acquired pneumonia who require mechanical ventilation and to determine the attributable morbidity and intensive care unit (ICU) mortality of community-acquired pneumonia. MATERIAL AND METHODS: Retrospective cohort study carried out in 361 ICUs from 20 countries including 124 patients who required mechanical ventilation on th...


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