2 documents found, page 1 of 1
Discovery of phenylsulfonylfuroxan derivatives as gamma globin inducers by hist...
Melo, Thais Regina Ferreira de [UNESP]; Kumkhaek, Chutima; Fernandes, Guilherme Felipe Dos Santos [UNESP]; Lopes Pires, Maria ElisaMade available in DSpace on 2018-12-11T17:37:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-06-25; N-oxide derivatives 5(a-b), 8(a-b), and 11(a-c) were designed, synthesized and evaluated in vitro and in vivo as potential drugs that are able to ameliorate sickle cell disease (SCD) symptoms. All of the compounds demonstrated the capacity to releasing nitric oxide at different levels ranging from 0.8 t...
Synthesis and biological activity of furoxan derivatives against Mycobacterium ...
Fernandes, Guilherme Felipe dos Santos [UNESP]; de Souza, Paula Carolina [UNESP]; Marino, Leonardo Biancolino [UNESP]; Chegaev, KonstantinMade available in DSpace on 2018-12-11T17:29:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-01-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Tuberculosis (TB) remains a serious health problem responsible to cause millions of deaths annually. The scenario becomes alarming when it is evaluated that the number of new drugs does not increase proportionally to the emergence of resista...