3 documents found, page 1 of 1
Seronegative Neuromyelitis Optica Spectrum - The challenges on disease definiti...
Sato,Douglas Kazutoshi; Callegaro,Dagoberto; Lana-Peixoto,Marco Aurélio; Nakashima,Ichiro; Fujihara,KazuoNeuromyelitis optica spectrum disorders (NMOSD) are characterized by severe optic neuritis and/or longitudinally extensive transverse myelitis, and some brain lesions are also unique to NMOSD. Serum autoantibodies against aquaporin-4 (AQP4) are detected in most cases of NMOSD. However, some patients with NMOSD remain seronegative despite repetitive testing during attacks with highly sensitive cell-based assays....
Treatment of neuromyelitis optica: an evidence based review
Sato,Douglas; Callegaro,Dagoberto; Lana-Peixoto,Marco Aurélio; Fujihara,KazuoNeuromyelitis optica (NMO) is an inflammatory disease of the central nervous system characterized by severe optic neuritis and transverse myelitis, usually with a relapsing course. Aquaporin-4 antibody is positive in a high percentage of NMO patients and it is directed against this water channel richly expressed on foot processes of astrocytes. Due to the severity of NMO attacks and the high risk for disability...
Atypical presentations of neuromyelitis optica
Sato,Douglas; Fujihara,KazuoNeuromyelitis optica (NMO) is an inflammatory disease of central nervous system classically characterized by acute, severe episodes of optic neuritis and longitudinally extensive transverse myelitis, usually with a relapsing course. The identification of an autoantibody exclusively detected in NMO patients against aquaporin-4 (AQP-4) has allowed identification of cases beyond the classical phenotype. Brain lesi...