13 documents found, page 1 of 2
Inhalation of dimethyl fumarate-encapsulated solid lipid nanoparticles attenuat...
Pinto, Barbara Fernandes; Ribeiro, Lorena Natasha Brito; Da Silva, Gisela Bevilacqua Rolfsen Ferreira [UNESP]; Freitas, Camila Simoes; Kraemer, LucasMade available in DSpace on 2022-04-29T08:38:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-01-01; Rationale: The FDA-approved Dimethyl Fumarate (DMF) as an oral drug for Multiple Sclerosis (MS) treatment based on its immunomodulatory activities. However, it also caused severe adverse effects mainly related to the gastrointestinal system. Objective: Investigated the potential effects of solid lipid n...
Development of the PraziCalc mobile device-app to calculate praziquantel dosage...
Viana, Agostinho Gonçalves; Coelho, André Luiz Gomes; Gazzinelli-Guimarães, Pedro Henrique; Phillips, Anna E.; Bartholomeu, Daniella Castanheira
Beneficial effects of Hibiscus rosa-sinensis L. flower aqueous extract in pregn...
Afiune, Luana Alves Freitas; Leal-Silva, Thaís; Sinzato, Yuri Karen [UNESP]; Moraes-Souza, Rafaianne Queiroz [UNESP]; Soares, Thaigra Sousa [UNESP]Made available in DSpace on 2018-12-11T17:12:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-06-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Purpose: The Hibiscus rosa-sinensis flower is widely used in Brazilian traditional medicine for the treatment of diabetes and has shown antifertility activity in female Wistar rats. However, there is no scientific confirmation of its ...
Electroacupuncture in rats infected with Strongyloides venezuelensis: Effects o...
Dos Anjos-Ramos, Luana; Gama, Loyane Almeida [UNESP]; Hauschildt, Andrieli Taise; Fujiwara, Ricardo Toshio; Corá, Luciana AparecidaMade available in DSpace on 2018-12-11T16:53:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-02-01; Objective To investigate the effects of electroacupuncture (EA) at ST36 and CV12 on gastrointestinal transit and parasitological measurements during Strongyloides venezuelensis infection in rats. Design Rats were infected with S. venezuelensis and allocated to one of three groups that were infected and ...
Regulatory monocytes in helminth infections: insights from the modulation durin...
Mendes, Tiago Antônio de Oliveira; Passos, Lívia Silva Araújo; Gazzinelli-Guimarães, Pedro Henrique; Guimarães, Ana Clara GazzinelliWhile the macrophage polarization is well characterized in helminth infections, the natural heterogeneity of monocytes with multiple cell phenotypes might influence the outcome of neglected diseases, such hookworm infection. Here, we report the profile of monocytes in human hookworm infections as a model to study the regulatory subpopulation of monocytes in helminth infections. Blood samples were collected from...
A new methodology for evaluation of nematode viability
Ferreira, Sebastião Rodrigo; Mendes, Tiago Antônio Oliveira; Bueno, Lilian Lacerda; Araújo, Jackson Victor de; Bartholomeu, Daniella CastanheiraNematodes infections are responsible for debilitating conditions and economic losses in domestic animals as well as livestock and are considered an important public health problem due to the high prevalence in humans. The nematode resistance for drugs has been reported for livestock, highlighting the importance for development of new anthelmintic compounds. The aim of the current study was to apply and compare ...
In vitro biological control of infective larvae of Ancylostoma ceylanicum
Fernandes, Fernanda Mara; Araújo, Jackson Victor; Braga, Fabio Ribeiro; Gazzinelli-Guimarães, Pedro Henrique; Araujo, Juliana MilaniO objetivo deste trabalho foi avaliar a atividade predatória do fungo Duddingtonia flagrans (AC001) sobre larvas infectantes de Ancylostoma ceylanicum após o trânsito gastrintestinal em hamsters. Foram utilizados vinte animais no experimento, divididos em dois grupos: um grupo tratado (10 animais) e um grupo controle (10 animais). No grupo tratado com D. flagrans, cada animal recebeu 5mg/25g de peso vivo de mic...
Impact of LbSapSal Vaccine in Canine Immunological and Parasitological Features...
Resende, Lucilene Aparecida; Soares, Rodrigo Dian de Oliveira Aguiar; Ker, Henrique Gama; Roatt, Bruno Mendes; Mendonça, Ludmila Zanandreis deFundação de Amparo a Pesquisa do Estado de Minas Gerais. Belo Horizonte, MG, Brazil; Universidade Federal de Minas Gerais. Departamento de Morfologia. Laboratório de Biologia das Interações Celulares. Belo Horizonte, MG, Brazil/Universidade Federal de Ouro Preto. Instituto de Ciências Exatas e Biológicas. Núcleo de Pesquisas em Ciências Biológicas/NUPEB Laboratório de Imunopatologia. Ouro Preto, MG, Brazil; Uni...
Multicomponent LBSap vaccine displays immunological and parasitological profile...
Mendonça, Ludmila Zanandreis de; Resende, Lucilene Aparecida; Lanna, Mariana Ferreira; Soares, Rodrigo Dian de Oliveira Aguiar; Roatt, Bruno MendesBackground: In past years, many researchers have sought canine visceral leishmaniasis (CVL) prevention through the characterization of Leishmania antigens as vaccine candidates. Despite these efforts, there is still no efficient vaccine for CVL control. Methods: In the present study, we performed a pre-clinical vaccine trial using BALB/c mice to compare the effects of the multicomponent LBSap vaccine with those...
Epitope mapping of the HSP83.1 protein of Leishmania braziliensis discloses nov...
Souza, Daniel Menezes; Mendes, Tiago Antônio de Oliveira; Gomes, Matheus de Souza; Cunha, João Luís Reis; Nagem, Ronaldo Alves PintoGold standard serological diagnostic methods focus on antigens that elicit a strong humoral immune response that is specific to a certain pathogen. In this study, we used bioinformatics approaches to identify linear B-cell epitopes that are conserved among Leishmania species but are divergent from the host species Homo sapiens and Canis familiaris and from Trypanosoma cruzi, the parasite that causes Chagas dise...