23 documents found, page 1 of 3
Mapping Biochemical Pathways in Maytenus ilicifolia (Celastraceae) through Inte...
Santos,Vânia A. F. F. M.; Dias,Nathalia B.; Teixeira,Simone P.; Palma,Mario S.; Furlan,MaysaMaytenus ilicifolia (Celastraceae) is a medicinal plant that is native to southern Brazil and is popularly known as “espinheira-santa”. From a biosynthesis perspective, this species accumulates quinonemethide triterpenes and sesquiterpene pyridine alkaloids as major secondary metabolites that exhibit interesting biological properties, with antitumoral and antiprotozoal activities, respectively, being the most f...
Trypanosoma cruzi: analysis of two different strains after piplartine treatment
Vieira,Gabriela Alves Licursi; Silva,Marco Túlio Alves da; Regasini,Luis Octávio; Cotinguiba,Fernando; Laure,Helen Julie; Rosa,José César; Furlan,MaysaABSTRACT The hemoflagellate protozoan, Trypanosoma cruzi, mainly transmitted by triatomine insects through blood transfusion or from mother-to-child, causes Chagas' disease. This is a serious parasitic disease that occurs in Latin America, with considerable social and economic impact. Nifurtimox and benznidazole, drugs indicated for treating infected persons, are effective in the acute phase, but poorly effecti...
Biosynthetic Insights into p-Hydroxybenzoic Acid-Derived Benzopyrans in Piper g...
Batista,Andrea N. L.; Batista Jr.,João M.; Souza-Moreira,Tatiana M.; Valentini,Sandro R.; Kato,Massuo J.; Zanelli,Cleslei F.; Furlan,MaysaPiper gaudichaudianum Kunth (Piperaceae) accumulates gaudichaudianic acid, a prenylated benzopyran, as its major component. Interestingly, this trypanocidal compound occurs as a racemic mixture. Herein, transcriptomic investigations of Piper gaudichaudianum using the RNA-seq approach are reported, and from the analysis of the transcripts expressed it was possible to propose a complete biosynthetic pathway for t...
Kavalactones and Benzoic Acid Derivatives from Leaves of Piper fuligineum Kunth...
Mazzeu,Bruna F.; Felippe,Lidiane G.; Cotinguiba,Fernando; Kato,Massuo J.; Furlan,MaysaThe known kavalactones (E)-4-methoxy-6-styryl-2H-pyran-2-one, 4-methoxy-6-(3-phenyloxiran-2-yl)-2H-pyran-2-one, 6-(1,2-dihydroxy-2-phenylethyl)-4-methoxy-2H-pyran-2-one, the three benzoic acid derivatives methyl-4-methoxy-3-(3'-methyl-2'-butenyl)benzoate and methyl 2,2-dimethyl-4-oxochroman-6-carboxylate, and a new methyl 4-methoxy-3-(3-methylbut-2-enoyl)benzoate were isolated from the ethanolic extract of Pipe...
SISTEMA NACIONAL DE PÓS-GRADUAÇÃO E A ÁREA DE QUÍMICA NA CAPES
Monteiro,Adriano L.; Furlan,Maysa; Suarez,Paulo A. Z.The Coordination for the Improvement of High Education Personnel (CAPES), the Brazilian federal agency for graduate programs, plays a fundamental role for the expansion and consolidation of the National Postgraduate System (SNPG) and the execution of the National Graduate Plan (PNPG) 2011-2020. In this paper, we discuss the evolution of the Brazilian graduate program in chemistry and its role in the formation o...
Synthetic Analogue of the Natural Product Piperlongumine as a Potent Inhibitor ...
Valli,Marilia; Altei,Wanessa; Santos,Ricardo N. dos; Lucca Jr.,Emilio C. de; Dessoy,Marco A.; Pioli,Renan M.; Cotinguiba,Fernando; Cachet,XavierPiperlongumine is a natural amide alkaloid isolated from several species of Piper and is described in the literature as selectively cytotoxic to several cancer cell lines. Inhibiting cell migration has gained considerable interest as an approach for discovering antimetastatic agents because this process is fundamental to metastasis. Piperlongumine, selected from cell-based assay screening of NuBBE Database, inh...
Tropical biodiversity: has it been a potential source of secondary metabolites ...
Valli,Marilia; Pivatto,Marcos; Danuello,Amanda; Castro-Gamboa,Ian; Silva,Dulce Helena Siqueira; Cavalheiro,Alberto José; Araújo,Ângela ReginaThe use of natural products has definitely been the most successful strategy in the discovery of novel medicines. Secondary metabolites from terrestrial and marine organisms have found considerable use in the treatment of numerous diseases and have been considered lead molecules both in their natural form and as templates for medicinal chemistry. This paper seeks to show the great value of secondary metabolites...
Aromatic compounds from three Brazilian Lauraceae species
Batista,Andrea Nastri de Luca; Batista Junior,João Marcos; López,Silvia Noelí; Furlan,Maysa; Cavalheiro,Alberto José; Silva,Dulce Helena SiqueiraPhytochemical investigations on three Brazilian Lauraceae species from the Cerrado region of São Paulo State, Ocotea corymbosa (Meins) Mez., O. elegans Mez. and Persea pyrifolia Nees & Mart. ex Nees resulted in the isolation of flavonoids, an ester of the 4-O-E-caffeoylquinic acid, an aromatic sesquiterpene besides furofuran lignans. This is the first chemical study on the leaves of Ocotea elegans and O. co...
Trypanocidal activity of Piper arboreum and Piper tuberculatum (Piperaceae)
Regasini,Luis Octávio; Cotinguiba,Fernando; Passerini,Gabriela Duó; Bolzani,Vanderlan da Silva; Cicarelli,Regina Maria Barretto; Kato,Massuo JorgeIn the scope of our ongoing research on bioactive agents from Brazilian flora, twenty-four extracts and fractions obtained from Piper arboreum Aub. and Piper tuberculatum Jacq. (Piperaceae) were screened for trypanocidal activity by using MTT colorimetric assay. The strongest activity was found in hexane fractions from the leaves of P. arboreum (IC50= 13.3 µg/ mL) and P. tuberculatum (IC50 = 17.2 µg/mL). Hexane...
Flavonas, lignanas e terpeno de Piper umbellata (Piperaceae)
Baldoqui,Debora Cristina; Bolzani,Vanderlan da S.; Furlan,Maysa; Kato,Massuo J.; Marques,Márcia O. M.The phytochemical investigation of Piper umbellata leaves yielded nine compounds including one terpenoid glucoside, five flavones (vitexin 2"-O-β-glucopyranoside, apigenin 8-C-β-D-glucopyranoside,orientin 8-C-β-D-glucopyranoside,5-hydroxy-7,3',4'-trimethoxy-flavone and velutin), two lignans (sesamin e dihydrocubebin) and 4-nerolidylcathecol. Excepting 4-nerolidylcathecol, all compounds have not been described f...