Laminin immobilization into diverse biological and synthetic matrices has been explored to replicate the microenvironment of stem cell niches and gain insight into the role of extracellular matrix (ECM) on stem cell behavior. However, the site-specific immobilization of this heterotrimeric glycoprotein and, consequently, control over its orientation and bioactivity has been a challenge that has limited many of ...
Background: Autopsy studies reveal that atherosclerosis lesions can be found as early as two years of age. To slow the development of this early pathology, obesity and dyslipidemia prevention should start from childhood making it urgent to explore new ways to evaluate dyslipidemia risk in children that can be applied widely, such as the non-invasive anthropometric evaluation. Objective: Assess the metabolic pro...
The authors report two cases of Adams-Oliver syndrome in 2-year-old children characterized by aplasia cutis congenita and terminal congenital abnormalities of the limbs. The diagnosis was made at birth and the aplasia cutis was associated with extensive skull defects, exposing the dural sinuses. The differences between the two patients were essentially the extension and the severity of the scalp and limb osteo-...
Reportam-se dois casos de doentes do sexo feminino com dois anos de idade e síndrome Adams-Oliver, que se caracteriza por um defeito congénito do escalpe e alterações malformativas congénitas dos membros, a que se associaram malformações e complicações do SNC. O diagnóstico foi feito à nascença e a aplasia cútis congénita caracterizava-se não só por extenso defeito no escalpe, mas também no osso subjacente, com...