2 documents found, page 1 of 1
Cholesteryl hemiazelate causes lysosome dysfunction impacting vascular smooth m...
Alves, Liliana S.; Marques, André R. A.; Padrão, Nuno; Carvalho, Filomena A.; Ramalho, José; Lopes, Catarina S.; Soares, Maria I. L.; Futter, Clare E.In atherosclerotic lesions, vascular smooth muscle cells (VSMCs) represent half of the foam cell population, which is characterized by an aberrant accumulation of undigested lipids within lysosomes. Loss of lysosome function impacts VSMC homeostasis and disease progression. Understanding the molecular mechanisms underlying lysosome dysfunction in these cells is, therefore, crucial. We identify cholesteryl hemia...
The Ternary Rab27a-Myrip-Myosin VIIa Complex Regulates Melanosome Motility in t...
Lopes, Vanda S.; Ramalho, José S.; Owen, Dylan M.; Karl, Mike O.; Strauss, Olaf; Futter, Clare E.; Seabra, Miguel C.The retinal pigment epithelium (RPE) contains melanosomes similar to those found in the skin melanocytes, which undergo dramatic light-dependent movements in fish and amphibians. In mammals, those movements are more subtle and appear to be regulated by the Rab27a GTPase and the unconventional myosin, Myosin VIIa (MyoVIIa). Here we address the hypothesis that a recently identified Rab27a- and MyoVIIa-interacting...