43 documents found, page 1 of 5
Vancomycin-Loaded, Nanohydroxyapatite-Based Scaffold for Osteomyelitis Treatmen...
Alegrete, N; Sousa, SR; Padrão, T; Carvalho, A; Lucas, R; Canadas, RF; Lavrador, C; Alexandre, N; Gärtner, F; Monteiro, FJ; Gutierres, MThe treatment for osteomyelitis consists of surgical debridement, filling of the dead space, soft tissue coverage, and intravenous administration of antimicrobial (AM) agents for long periods. Biomaterials for local delivery of AM agents, while providing controllable antibiotic release rates and simultaneously acting as a bone scaffold, may be a valuable alternative; thus, avoiding systemic AM side effects. V-H...
E-cadherin Expression in Canine Gastric Carcinomas: Association with Clinicopat...
Flores, AR; Rêma, A; Mesquita, JR; Taulescu, M; Seixas, F; Gärtner, F; Amorim, IE-cadherin (E-cad) is a cell-adhesion molecule known for its tumor-invasion suppressor function. E-cad expression was examined immunohistochemically in a series of canine tissue samples, including normal gastric mucosa (NGM; n = 3), gastric carcinomas (GC; n = 33), adjacent nonneoplastic mucosa (NNM; n = 32), neoplastic emboli (n = 16) and metastatic lesions (n = 9). The relationship between E-cad expression an...
Molecular detection of Helicobacter spp. and Fusobacterium gastrosuis in pigs a...
Cortez Nunes, F; Letra, Mateus, T; Taillieu, E; Teixeira, S; Carolino, N; Rema, A; De Bruyckere, S; Gärtner, F; Haesebrouck, F; Amorim, IBesides Helicobacter pylori, a Gram-negative bacterium that may cause gastric disorders in humans, non-Helicobacter pylori helicobacters (NHPH) may also colonize the stomach of humans and animals. In pigs, H. suis can induce gastritis and may play a role in gastric ulcer disease, possibly in association with Fusobacterium gastrosuis. In the present study, gastric samples from 71 slaughtered pigs and 14 hunted f...
Helicobacter spp. in the Stomach of Cats: Successful Colonization and Absence o...
Teixeira, S; Filipe, D; Cerqueira, M; Barradas, P; Nunes, FC; Faria, F; Haesebrouck, F; Mesquita, JR; Gärtner, F; Amorim, IIn addition to Helicobacter pylori, many non-Helicobacter pylori Helicobacters (NHPH) are able to cause gastric disease in humans. Cats are a natural reservoir for many of these species. Accordingly, living in close and intimate contact with animals has been identified as a risk factor, and an important zoonotic significance has therefore been attributed to NHPH. To determine the prevalence and associated gastr...
Retrospective study of canine cutaneous tumors submitted to a diagnostic pathol...
Martins, AL; Canadas-Sousa, A; Mesquita, JR; Dias-Pereira, P; Amorim, I; Gärtner, FBackground Cutaneous neoplastic diseases are the most and second-most frequently reported tumors in male and female dogs, respectively. The aims of this study were to report the occurrence of canine cutaneous tumors in a pathology laboratory located in Northern Portugal between 2014 and 2020, and to characterize and categorize the anatomical locations, breed, age, and sex of the animals affected with different ...
Nipple Hibernoma in a Dog: A Case Report With Literature Review
Amorim, I; Faria, F; Taulescu, M; Taulescu, C; Gärtner, FThis report provides a clinical, histological, and immunohistochemical description of an unusual hibernoma (pale cell variant) in the subepidermal area of the nipple of a six-year-old bitch. Furthermore, an extensive literature review of hibernomas in animals was made. Physical examination revealed a nodular lesion in the subepidermal area of the third nipple of the left mammary chain. The histopathological fin...
Relationship between PD-L1 expression and tumor-infiltrating lymphocytes in can...
Lopes-Neto, BE; Nunes-Pinheiro, DCS; Carvalheira, JGV; Schmitt, F; Gärtner, FBackground: Studies pointed out that the tumor-infiltrating lymphocytes (TILs) have considerable importance in canine mammary tumor (CMT). On the other hand, cancer cells sometimes find ways to use immune checkpoint proteins as a shield to avoid being identified and attacked by the immune system as programmed death 1 ligand 1 (PD-L1). In this study, it was investigated the relationship between PD-L1 expression,...
New insight into breast cancer cells involving drug combinations for dopamine a...
Costa, B; Matos, R; Amorim, I; Gärtner, F; Vale, NThe breast cancer therapies available are insufficient, especially since first-line treatments, such as paclitaxel, result in drug resistance and their toxicity often limits their concentration. Strategies like drug repurposing are beneficial, and novel treatments can emerge by repurposing drugs that interfere with the dopamine and serotonin receptors, and thus influence tumor growth. In this study, the MTT ass...
Molecular identification and characterization of Rickettsia spp. and other tick...
Barradas, PF; Mesquita, JR; Ferreira, P; Gärtner, F; Carvalho, M; Inácio, E; Chivinde, E; Katimba, A; Amorim, ITicks are one of the most common vectors of a broad variety of pathogenic agents that significantly affects cattle production causing reduced productivity and important economic losses, while simultaneously having an impact on human health due to the zoonotic risk. In much of the territory of Angola urban population has grown rapidly in recent decades, sharing today close contact with large farms that are gener...
High drug resistance in feline mammary carcinoma cell line (FMCm) and compariso...
Correia, AS; Matos, R; Gärtner, F; Amorim, I; Vale, NDrug repurposing and drug combination are important therapeutic approaches in cancer therapy. Drug repurposing aims to give new indications to drugs, rather than the original indication, whereas drug combination presupposes that the effect that is obtained should be more beneficial than the effect obtained by the individual drugs. Previously, drug repurposing and the combination of different drugs was evaluated...