Trastuzumab Deruxtecan is indicated for the treatment of Human Epidermal growth factor Receptor-type 2 HER2-positive or HER2-low breast cancer, showing favorable efficacy and safety profiles. However, it can lead to some severe adverse events, such as interstitial lung disease. We performed four regional experience sharing sessions and one final national discussion session, with the participation of several nur...
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Objective: In patients with type 2 diabetes mellitus, depressive symptoms may be associated with metabolic deterioration. The impact of sex on this association is unclear. The aim of this study is to analyze the relationship between depression and metabolic control by sex. The data presented is the side product of the clinical investigation by Rui Duarte, MD, Treatment Response in Type 2 Diabetes Patients with ...
Depressive symptoms and suicidal behavior are common among patients that suffered a first-episode psychosis. We searched Web of KnowledgeSM and Pubmed® for English and Portuguese original articles investigating prevalence of depressive symptoms and/or suicidal behavior and associated factors after first-episode psychosis. We included 19 studies from 12 countries, 7 studied depressive symptoms and 12 suicidal be...
Objectives: To determine the cost associated with the preparation and administration of intravenous (IV) trastuzumab and to estimate the difference versus subcutaneous (SC) administration considering only the consumption of material resources (MR) and the cost associated with the time spent by the health professionals (HP) involved.Study Design: Cross-sectional study of resource consumption evaluation by interv...
Hyperprolactinemia is a common, but neglected, adverse effect of conventional antipschycotics and of some of the atypical antipshycotics. It occurs in almost 42% of men and in 75% of women with schizophrenia who are treated with prolactin-raising antipshycotics, even though it has aroused minimal interest within the scientific community when compared with extra-pyramidal effects. Conventional antipsychotics and...
Club drugs are the following substances: Methylenedioxymethamphetamine (MDMA); Methamphetamine; Lysergic Acid Diethylamide (LSD); Ketamine; Gamma-hydroxybutyrate (GHB) and Flunitrazepam. These substances are mainly used by adolescents and young adults, mostly in recreational settings like dance clubs and rave parties. These drugs have diverse psychotropic effects, are associated with several degrees of toxicity...
The Metabolic Syndrome (MS) is constituted by a set of specific metabolic alterations being postulated that the main dysfunction is insulin resistance, associated with abdominal type obesity, hypertension, hyperglycemia and dyslipidemia. Epidemiological data indicates prevalence of MS of about 25%. Estimates point to higher prevalence of MS in bipolar (BP) patients, between 30 to 35%. Cost-effective screening m...
Lack of insight into mental disorder is a frequent phenomenon in patients affected by a psychotic disorder and can be an important predicting factor involving the course of the disease mainly regarding compliance with treatment. The aim of the present study was to validate the Portuguese version of the Marková and Berrios Insight Scale, a self-report instrument that allow us to evaluate insight into psychotic i...