12 documents found, page 1 of 2

Membranous Nephropathy as a Manifestation of IgG4‑Related Disease (IgG4‑RD): A ...

Abstract IgG4‑related disease (IgG4‑RD) is an immune‑mediated, inflammatory condition that can affect multiple organs, marked by lymphoplasmocytic infiltration and IgG4‑positive plasma cells. Elevated serum IgG4 is common but not essential. Sole renal manifestation is rare, usually appearing as tubulointerstitial nephritis (TIN) or, less commonly, membranous nephropathy (MN). We present a case of an 87‑year‑old...

Relapsing Nephrotic Syndrome Case: A Two­Sided Pathway

Tough Decision Making in Pembrolizumab-Associated Acute Interstitial Nephritis:...

ABSTRACT Pembrolizumab is an immune checkpoint inhibitor used as a cancer therapy. The incidence of immune related adverse events in patients receiving immune checkpoint inhibitors can be as high as 59%-85. Renal adverse effects are uncommon, but the incidence of kidney toxicity related to pembrolizumab is rising as the use of this agent becomes more frequent. We present an uncommon case of biopsy-proven acute ...

Nephrotic Syndrome and Waldenstrom’s Macroglobulinemia: A Case Report

ABSTRACT Waldenstrom’s macroglobulinemia (WM) is an IgM associated lymphoplasmacytic lymphoma and kidney disease is a rare complication. We report a case of a 41-year-old male with a history of WM diagnosed 16 years ago, currently with no indication for treatment. The patient presented with nephrotic syndrome and acute kidney injury, hypertension, and multiple lymphadenopathies. A kidney biopsy was performed, s...

Behind a Paralyzing Pandemic: Renal Cortical Necrosis

ABSTRACT Renal cortical necrosis (RCN) is a rare cause of acute kidney injury (AKI) in developed countries. Drugs, especially non-steroidal antiinflammatory drugs, (NSAIDs) are very rarely described in the literature to cause cortical necrosis. It is characterized by confluent necrosis of the entire cortex apart from a thin rim of viable tissue in the subcapsular, juxtaglomerular areas, and medulla. Although th...

The Prognostic Value of Histopathological Classifications in ANCA-Associated Va...

ABSTRACT Renal involvement is a common and severe feature of ANCA-associated vasculitis, leading to end-stage kidney disease and death in a considerable number of patients. One of the challenges of ANCA-associated glomerulonephritis is to establish histological features of prognostic value, in order to identify patients who will benefit of immunosuppression. Although the prognostic value of the renal biopsy in ...

Acute kidney injury associated with COVID-19 infection: a case report

ABSTRACT SARS-Cov2 infection is a highly transmissible disease associated with serious pulmonary disease. Renal involvement is frequent and associated with poor prognosis; however, mechanisms of kidney injury are not well established. We present a SARS-Cov2 patient with severe acute kidney injury. Kidney biopsy findings revealed a pattern of acute tubular necrosis with isometric vacuolization of the proximal tu...

From membranoproliferative glomerulonephritis to a final diagnosis: Hypocomplem...

ABSTRACT Membranoproliferative glomerulonephritis describes a glomerular-injury pattern common to a heterogeneous group of diseases. Evaluation based on clinical and laboratory presentation and immunofluorescence staining on kidney biopsy allows identification of underlying pathophysiological processes and may facilitate proper diagnosis and treatment. Hypocomplementemic urticarial vasculitis syndrome is a rare...

From light chain deposition to multiple myeloma - Case report and literature re...

Monoclonal gammopathies consist of a broad spectrum of diseases, ranging from asymptomatic monoclonal gammopathy of undetermined significance to multiple myeloma (MM). Multiple myeloma is a malignant plasma cell disorder and accounts for 10% of all hematological malignancies and 1% of all malignancies. Differential diagnosis may be challenging, considering the variety of clinical entities with similar behavior....

Pathology turned its back on semiology