11 documents found, page 1 of 2
Phytotherapy and nutritional supplements on breast cancer
Lopes, Carla Martins; Dourado, A.; Oliveira, RitaBreast cancer is the most frequent type of nonskin malignancy among women worldwide. In general, conventional cancer treatment options (i.e., surgery, radiotherapy, chemotherapy, biological therapy, and hormone therapy) are not completely effective. Recurrence and other pathologic situations are still an issue in breast cancer patients due to side effects, toxicity of drugs in normal cells, and aggressive behav...
Slow modulations of high-frequency activity (40-140-Hz) discriminate preictal c...
Alvarado-Rojas, C; Valderrama, M; Fouad-Ahmed, A; Feldwisch-Drentrup, H; Ihle, M; Teixeira, C. A.; Sales, F.; Schulze-Bonhage, A; Adam, C; Dourado, A.Recent evidence suggests that some seizures are preceded by preictal changes that start from minutes to hours before an ictal event. Nevertheless an adequate statistical evaluation in a large database of continuous multiday recordings is still missing. Here, we investigated the existence of preictal changes in long-term intracranial recordings from 53 patients with intractable partial epilepsy (in total 531 day...
Genome-wide scan in Portuguese Island families identifies 5q31-5q35 as a suscep...
Sklar, P.; Pato, Michele T.; Kirby, A. N.; Petryshen, T. L.; Medeiros, Helena; Carvalho, Célia; Macedo, António; Dourado, A.; Coelho, I.; Valente, J.Schizophrenia is a common psychiatric disorder with a complex genetic etiology. To understand the genetic basis of this syndrome in Portuguese Island populations, we performed a genome-wide scan of 29 families with schizophrenia, which identified a single region on 5q31-5q35 with strong linkage (NPL=3.09, P=0.0012 at D5S820). Empirical simulations set a genome-wide threshold of NPL=3.10 for significant linkage....
Genome-wide scan in Portuguese Island families implicates multiple loci in bipo...
Pato, Carlos N.; Pato, Michele T.; Kirby, A. N.; Petryshen, T. L.; Medeiros, Helena; Carvalho, Célia; Macedo, António; Dourado, A.; Coelho, I.As part of an extensive study in the Portuguese Island population of families with multiple patients suffering from bipolar disorder and schizophrenia, we performed an initial genome-wide scan of 16 extended families with bipolar disorder that identified three regions on chromosomes 2, 11, and 19 with genome-wide suggestive linkage and several other regions, including chromosome 6q, also approached suggestive l...
A vision-based system for automatic growing ring detection and measurement
Vaz, C.; Carvalho, P.; Duarte, F.; Dourado, A.An automatic visual inspection system for wood growing ring identification and measurement is described. Given the irregular contrast distributions in wood samples, the identification of these elements is not straightforward. Furthermore, it is observed that many rings exhibit very narrow widths. To overcome these problems, several new methods are introduced, namely at the local image scale definition and at th...
Genome-wide scan in Portuguese Island families implicates multiple loci in bipo...
Pato, Carlos N.; Pato, M. T.; Kirby, A.; Petryshen, T. L.; Medeiros, H.; Carvalho, C.; Macedo, A.; Dourado, A.; Coelho, I.; Valente, J.; Soares, M. J.As part of an extensive study in the Portuguese Island population of families with multiple patients suffering from bipolar disorder and schizophrenia, we performed an initial genome-wide scan of 16 extended families with bipolar disorder that identified three regions on chromosomes 2, 11, and 19 with genome-wide suggestive linkage and several other regions, including chromosome 6q, also approached suggestive l...
Genomewide Linkage Analysis of Bipolar Disorder by Use of a High Density Single...
Middleton, Frank A.; Pato, Michele T.; Gentile, Karen; Morley, C. P.; Zhao, X.; Eisener, A. F.; Brown, A.; Petryshen, T. L.; Kirby, A. N.We performed a linkage analysis on 25 extended multiplex Portuguese families segregating for bipolar disorder, by use of a high-density single-nucleotide-polymorphism (SNP) genotyping assay, the GeneChip Human Mapping 10K Array (HMA10K). Of these families, 12 were used for a direct comparison of the HMA10K with the traditional 10-cM microsatellite marker set and the more dense 4-cM marker set. This comparative ...
Adaptive RBFNN versus conventional self-tuning: comparison of two parametric mo...
Pereira, C.; Henriques, J.; Dourado, A.In this work a practical study evaluates two parametric modelling approaches -- linear and non-linear (neural) -- for automatic adaptive control. The neural adaptive control is based on a developed hybrid learning technique using an adaptive (on-line) learning rate for a Gaussian radial basis function neural network. The linear approach is used for a self-tuning pole-placement controller. A selective forgetting...
An automatic system for dirt in pulp inspection using hierarchical image segmen...
Duarte, F.; Araújo, H.; Dourado, A.An automatic visual inspection system designed for dirt inspection in the pulp and paper industry is presented. A new hierarchical region oriented segmentation algorithm is introduced. The algorithm is tuned according to the singular characteristics of the pulp samples. A criterion based on the maximisation of the local contrast is defined in order to perform a defect region segmentation of the pulp and paper i...
An automatic optical sensor for vessels and fibbers quality inspection in pulp ...
Carvalho, P.; Araújo, H.; Dourado, A.Wood quality assessment is an important issue in the pulp and paper industry. In this paper an automatic visual inspection system for wood structural quality measurement is described. To improve statistical image segmentation a new logarithm based global contrast enhancement technique is described. Region identification and reconstruction is performed based on local morphological operators with constrained merg...