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Smaug1 membrane-less organelles respond to AMPK and mTOR and affect mitochondri...

Fernández-Alvarez, Ana J.; Gabriela Thomas, María; Pascual, Malena L.; Habif, Martín; Pimentel, Jerónimo; Corbat, Agustín A.; Pessoa, João

Smaug is a conserved translational regulator that binds numerous mRNAs, including nuclear transcripts that encode mitochondrial enzymes. Smaug orthologs form cytosolic membrane-less organelles (MLOs) in several organisms and cell types. We have performed single-molecule fluorescence in situ hybridization (FISH) assays that revealed that SDHB and UQCRC1 mRNAs associate with Smaug1 bodies in U2OS cells. Loss of f...

Date: 2022   |   Origin: Repositório da Universidade de Lisboa
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