2 documents found, page 1 of 1
Host determinants of infectiousness in smear-positive patients with pulmonary t...
Acuña-Villaorduña, Carlos; Ayakaka, Irene; Schmidt-Castellani, Luiz Guilherme; Mumbowa, Francis; Marques-Rodrigues, Patricia; Gaeddert, MaryBackground Epidemiologic data suggests that only a minority of tuberculosis (TB) patients are infectious. Cough aerosol sampling is a novel quantitative method to measure TB infectiousness. Methods We analyzed data from three studies conducted in Uganda and Brazil over a 13-year period. We included sputum acid fast bacilli (AFB) and culture positive pulmonary TB patients and used a cough aerosol sampling system...
Cough-Aerosol cultures of Mycobacterium tuberculosis in the prediction of outco...
Acuña-Villaorduña, Carlos; Schmidt-Castellani, Luiz Guilherme; Marques-Rodrigues, Patricia; White, Laura F.; Hadad, David Jamil; Gaeddert, MaryBackground Mycobacterium tuberculosis cultures of cough-generated aerosols from patients with pulmonary tuberculosis (TB) are a quantitative method to measure infectiousness and to predict secondary outcomes in exposed contacts. However, their reproducibility has not been established. Objective To evaluate the predictive value of colony-forming units (CFU) of M.Tuberculosis in cough aerosols on secondary infect...