7 documents found, page 1 of 1
Local adaptation in populations of Mycobacterium tuberculosis endemic to the In...
Menardo, Fabrizio; Rutaihwa, Liliana K; Zwyer, Michaela; Borrell, Sonia; Comas, I?aki; Concei??o, Emilyn Costa; Cascolla, Mireia; Cox, HellenThis work was supported by the Swiss National Science Foundation (grants 310030_188888, CRSII5_177163, IZRJZ3_164171 and IZLSZ3_170834) and the European Research Council (309540?EVODRTB and 883582-ECOEVODRTB); Swiss Tropical and Public Health Institute. Department of Medical Parasitology and Infection Biology. Basel, Switzerland / University of Basel. Basel, Switzerland.; Swiss Tropical and Public Health Instit...
Evaluation of drug susceptibility profile of mycobacterium tuberculosis lineage...
Guimar?es, Arthur Emil dos Santos; Sharma, Abhinav; Furlaneto, Ismari Perini; Rutaihwa, Liliana; Cardoso, Jedson Ferreira; Concei??o, Mar?lia Lima daCNPq (207,071/2014-4), CAPES (Finance Code 001), Swiss National Science Foundation (grants 310030_166687 and IZRJZ3_164171); Universidade do Estado do Par?. Instituto de Ci?ncias Biol?gicas e da Sa?de. P?s-Gradua??o em Biologia Parasit?ria na Amaz?nia. Bel?m, PA, Brasil / Minist?rio da Sa?de. Secretaria de Vigil?ncia em Sa?de. Instituto Evandro Chagas. Ananindeua, PA, Brasil.; International Institute of Informa...
Mycobacterium tuberculosis lineage 1 genetic diversity in Par?, Brazil, suggest...
Concei??o, Emilyn Costa; Refregier, Guislaine; Gomes, Harrison Magdinier; Olessa-Daragon, Xavier; Coll, Francesc; Ratovonirina, Noel HarijaonaUniversit? Paris-Sud. Universit? Paris Saclay. Institut de Biologie Int?grative de la Cellule. I2BC. UMR9198. CEA. CNRS. Gif-sur-Yvette cedex, France / Universidade Federal do Rio de Janeiro. P?s-Gradua??o Instituto de Microbiologia Professor Paulo de G?es. Rio de Janeiro, RJ, Brazil.; Universit? Paris-Sud. Universit? Paris Saclay. Institut de Biologie Int?grative de la Cellule. I2BC. UMR9198. CEA. CNRS. Gif-su...
Analysis of potential household transmission events of tuberculosis in the city...
Concei??o, Emilyn Costa; Guimar?es, Arthur Emil dos Santos; Lopes, Maria Lu?za; Furlaneto, Ismari Perini; Rodrigues, Yan Corr?aThis work was funded by Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior (CAPES), Institut d'Estudis Catalans (IEC) and the Swiss National Science Foundation (grants 310030_166687 and IZRJZ3_164171).; Universidade Federal do Rio de Janeiro. Instituto de Microbiologia Paulo de Go?s. Rio de Janeiro, RJ, Brazil.; Universidade do Estado do Par?. Programa de P?s-gradua??o em Biologia Parasit?ria na Amaz?n...
The troika host-pathogen-extrinsic factors in tuberculosis: modulating inflamma...
Bastos, Hélder Novais; Osório, Nuno S.; Gagneux, Sebastien; Comas, Iñaki; Saraiva, MargaridaThe already enormous burden caused by tuberculosis (TB) will be further aggravated by the association of this disease with modern epidemics, as human immunodeficiency virus and diabetes. Furthermore, the increasingly aging population and the wider use of suppressive immune therapies hold the potential to enhance the incidence of TB. New preventive and therapeutic strategies based on recent advances on our under...
Mycobacterium tuberculosis lineage 4 comprises globally distributed and geograp...
Stucki, David; Brites, Daniela; Jeljeli, Leïla; Coscolla, Mireia; Liu, Qingyun; Trauner, Andrej; Fenner, Lukas; Rutaihwa, Liliana; Borrell, SoniaGeneralist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, sugges...
Evidence for diversifying selection in a set of Mycobacterium tuberculosis gene...
Osório, Nuno S.; Rodrigues, Fernando; Gagneux, Sebastien; Pedrosa, Jorge; Pinto-Carbó, Marta; Castro, António G.; Young, Douglas; Comas, IñakiTuberculosis (TB) is a global health problem estimated to kill 1.4 million people per year. Recent advances in the genomics of the causative agents of TB, bacteria known as the Mycobacterium tuberculosis complex (MTBC), have allowed a better comprehension of its population structure and provided the foundation for molecular evolution analyses. These studies are crucial for a better understanding of TB, includin...