18 documents found, page 1 of 2

BioMarrow

Preclinical models for multiple myeloma (MM) often fail to recapitulate the complexity of the bone marrow (BM) microenvironment, limiting their utility for drug testing and translational research. There is an urgent need for physiologically relevant, patient-adaptable platforms to support personalized therapeutic evaluation. We developed BioMarrow, a 3D ex vivo BM culture system using unmanipulated patient BM a...

Diagnosis and Laboratory Follow-Up of Patients with Multiple Myeloma: Guideline...

Multiple myeloma is a neoplasm of plasma cells that in most cases is associated with the secretion of monoclonal immunoglobulins and can involve multiple organs. Its timely diagnosis is essential to limit or avoid irreversible damage and dysfunction of target organs. Appropriate initial stratification of patients allows for optimization in the selection and sequence of therapy, as well as proper follow-up durin...

Diagnosis and laboratory follow-up of patients with multiple myeloma: guideline...

Multiple myeloma is a neoplasm of plasma cells that in most cases is associated with the secretion of monoclonal immunoglobulins and can involve multiple organs. Its timely diagnosis is essential to limit or avoid irreversible damage and dysfunction of target organs. Appropriate initial stratification of patients allows for optimization in the selection and sequence of therapy, as well as proper follow-up durin...

Cold-Induced Skin Perfusion Adaptive Responses

Funding Information: This study was supported by FCT\u2014Foundation for Science and Technology, I.P. (Portugal), under the (UIDB/04567/2020) and (UIDP/04567/2020) programs. Imaging instrumentation provided by ALIES-COFAC. The authors would like to express their thanks to Marisa Nicolai and to all participants. Publisher Copyright: © 2025 ALIES. All rights reserved.; Ice cooling exposure (ICE) is an interesting...

Contribution of Nailfold Videocapillaroscopy to the Diagnosis of Connective Tis...

Cover Page and List of Contents

Cover Page and List of Contents

Preface

Preface to VIA PANORAMICA Vol. 14 N2

Cold-induced skin perfusion adaptive responses : comparing ICE and PORH mechani...

O arrefecimento por exposição pelo gelo (AEG) é uma técnica interessante embora pouco explorada para examinar os mecanismos adaptativos da microcirculação periférica humana. Neste estudo, comparamos as alterações de perfusão in vivo avaliadas por fluxometria laser Doppler (LDF) envolvendo a hiperemia reactiva pósoclusão (HRPO) e o AEG. Onze mulheres saudáveis, com 29,3±7,3 anos de idade, foram selecionadas e su...

Diagnóstico e Seguimento Laboratorial de Doentes com Mieloma Múltiplo

Multiple myeloma is a neoplasm of plasma cells that in most cases is associated with the secretion of monoclonal immunoglobulins and can involve multiple organs. Its timely diagnosis is essential to limit or avoid irreversible damage and dysfunction of target organs. Appropriate initial stratification of patients allows for optimization in the selection and sequence of therapy, as well as proper follow-up durin...

Multiple Myeloma Laboratory Diagnostics Made Simple

Publisher Copyright: © 2025 by the authors.; Multiple myeloma is a clonal plasma cell malignancy with a highly variable range of clinical manifestations. Over recent decades, substantial progress has been made in laboratory diagnostics, which has deepened our understanding of disease biology, improved risk stratification, and informed treatment strategies. In an era of transformation and innovation, conventiona...