2 documents found, page 1 of 1
Multi-biomarker responses of Asian clam Corbicula fluminea (bivalvia, corbiculi...
Parra, S; Varandas, S; Santos, D; Félix, LM; Fernandes, L; Cabecinha, E; Gago, J; Monteiro, SMOne of the most widespread aquatic organisms in the rivers and estuarine ecosystems, in the world, is Asian clam Corbicula fluminea. This clam, that can adapt to environmental changes, is an invasive species in several areas and it was adopted as a model for toxicity tests. This study evaluated the effects of the exposure to cadmium (Cd), to microplastics (MPs) and their mixtures on C. fluminea. The oxidative s...
Zebrafish xenografts as a fast screening platform for bevacizumab cancer therapy
Almeida, C; Mendes, R; Pezzarossa, A; Gago, J; Carvalho, C; Alves, A, et al.Cancer is the second leading cause of death in the world. Given that cancer is a highly individualized disease, predicting the best chemotherapeutic treatment for individual patients can be difficult. Ex vivo models such as mouse patient-derived xenografts (PDX) and organoids are being developed to predict patient-specific chemosensitivity profiles before treatment in the clinic. Although promising, these model...