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Maternal hemoglobin and iron status in early pregnancy and childhood cardiac ou...

Quezada-Pinedo, HG; Jaddoe, V; Gaillard, R; Duijts, L; van Rijn, B; Reiss, IKM; Vermeulen, MJ; Santos, S

Background & aims: Dysregulation of iron homeostasis is associated with cardiac alterations in a sex-dependent manner in adults. It is unknown whether iron status during pregnancy has long-term impact on cardiovascular health, and if this association is influenced by sex. Therefore, this study aimed to evaluate sex-specific association between maternal iron status during early pregnancy and cardiac outcomes in ...


Long-term cardiometabolic health in people born after assisted reproductive tec...

Elhakeem, A; Taylor, AE; Inskip, HM; Huang, JY; Mansell, T; Rodrigues, C; Asta, F; Blaauwendraad, SM; Haberg, SE; Halliday, J; Harskamp-van Ginkel, MW

Aims To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age. Methods and results Differences in systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), lipids, and hyperglycaemic/insulin resistance markers were examined using multiple linear regression models in 14 popu...


Associations of maternal urinary bisphenol and phthalate concentrations with of...

Blaauwendraad, SM; Jaddoe, VW; Santos, S; Kannan, K; Dohle, GR; Trasande, L; Gaillard, R

Fetal exposure to bisphenols and phthalates may influence development of the reproductive system. In a population-based, prospective cohort study of 1059 mother-child pairs, we examined the associations of maternal gestational urinary bisphenols and phthalates concentrations with offspring reproductive development from infancy until 13 years. We measured urinary bisphenol and phthalate concentrations in each tr...


Changes in parental smoking during pregnancy and risks of adverse birth outcome...

Philips, EM; Santos, S; Trasande, L; Aurrekoetxea, JJ; Barros, H; von Berg, A; Bergström, A; Bird, PK; Brescianini, S; Ní Chaoimh, C; Charles, MA

Background. Fetal smoke exposure is a common and key avoidable risk factor for birth complications and seems to influence later risk of overweight. It is unclear whether this increased risk is also present if mothers smoke during the first trimester only or reduce the number of cigarettes during pregnancy, or when only fathers smoke. We aimed to assess the associations of parental smoking during pregnancy, spec...


Maternal body mass index, gestational weight gain, and the risk of overweight a...

Voerman, E; Santos, S; Patro Golab, B; Amiano, P; Ballester, F; Barros, H; Bergström, A; Charles, MA; Chatzi, L; Chevrier, C; Chrousos, GP

Maternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the extremes of maternal body mass index (BMI) and gestational weight gain. We aimed to assess the separate and combined associations of maternal BMI and gestational weight gai...


Impact of maternal body mass index and gestational weight gain on pregnancy com...

Santos, S; Voerman, E; Amiano, P; Barros, H; Beilin, LJ; Bergström, A; Charles, MA; Chatzi, L; Chevrier, C; Chrousos, GP; Corpeleijn, E; Costa, O

Objective To assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact. Design Individual participant data meta-analysis of 39 cohorts. Setting Europe, North America, and Oceania. Population 265 270 births. Methods Information on maternal pre-pregnancy BMI, gestational weight gai...


Gestational weight gain charts for different body mass index groups for women i...

Santos, S; Eekhout, I; Voerman, E; Gaillard, R; Barros, H; Charles, MA; Chatzi, L; Chevrier, C; Chrousos, GP; Corpeleijn, E; Costet, N; Crozier, S

BackgroundGestational weight gain differs according to pre-pregnancy body mass index and is related to the risks of adverse maternal and child health outcomes. Gestational weight gain charts for women in different pre-pregnancy body mass index groups enable identification of women and offspring at risk for adverse health outcomes. We aimed to construct gestational weight gain reference charts for underweight, n...


Associations of maternal obesity and excessive weight gain during pregnancy wit...

Jharap, VV; Santos, S; Steegers, EAP; Jaddoe, VWV; Gaillard, R

Background: Not much is known about the associations of maternal obesity and excessive gestational weight gain with body fat in infancy. Objective: To examine the associations of maternal pre-pregnancy body mass index and gestational weight gain with infant subcutaneous fat. Methods: In a population-based prospective cohort study among 845 mothers and their infants, we obtained maternal pre-pregnancy body mass ...


Fish Intake in Pregnancy and Child Growth A Pooled Analysis of 15 European and ...

Stratakis, N; Roumeliotaki, T; Oken, E; Barros, H; Basterrechea, M; Charles, MA; Eggesbo, M; Forastiere, F; Gaillard, R; Gehring, U; Govarts, E

IMPORTANCE: Maternal fish intake in pregnancy has been shown to influence fetal growth. The extent to which fish intake affects childhood growth and obesity remains unclear. OBJECTIVE:To examine whether fish intake in pregnancy is associated with offspring growth and the risk of childhood overweight and obesity. DESIGN, SETTING, AND PARTICIPANTS:Multicenter, population-based birth cohort study of singleton deli...


Maternal plasma n-3 and n-6 polyunsaturated fatty acid concentrations during pr...

Jelena Vidakovic, A; Santos, S; Williams, MA; Duijts, L; Hofman, A; Demmelmair, H; Koletzko, B; Jaddoe, VW; Gaillard, R

OBJECTIVE:The associations of maternal plasma n-3 and n-6 polyunsaturated fatty acid (PUFA) concentrations during pregnancy with infant subcutaneous fat were examined. METHODS:In a population-based prospective cohort study among 904 mothers and their infants, maternal plasma n-3 and n-6 PUFA concentrations were measured at midpregnancy. Body mass index, total subcutaneous fat, and central-to-total subcutaneous ...


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