7 documents found, page 1 of 1
Effectiveness of the autumn 2023 COVID-19 vaccine dose in hospital-based health...
Savulescu, Camelia; Prats-Uribe, Albert; Brolin, Kim; Uusküla, Anneli; Bergin, Colm; Fleming, Catherine; Murri, Rita; Zvirbulis, ViestursCOVID-19 vaccination recommendations prioritise healthcare workers (HCWs), considering their exposure to severe acute respiratory coronavirus 2 (SARS-CoV-2) and their key role in the functioning of healthcare systems. In the European Union/European Economic Area (EU/EEA), HCWs were considered a priority for COVID-19 revaccination during the autumn 2023 campaign [1], and the World Health Organization (WHO) recom...
codY and pdhA expression is induced in Staphylococcus epidermidis biofilm and p...
Gaio, Vania; Lopes, Nathalie; Cerca, Nuno; França, Ângela Maria Oliveira SousaStaphylococcus epidermidis biofilm cells can enter a physiological state known as viable but non-culturable (VBNC), where, despite being alive, they do not grow in conventional laboratory media. As such, the presence of VBNC cells impacts the diagnosis of S. epidermidis biofilm-associated infections. Previous transcriptomics analysis of S. epidermidis strain 9142 biofilms with higher proportions of VBNC cells s...
Prevalence of anemia in the Portuguese adult population: results from the first...
Samões, Catarina; Kislaya, Irina; Sousa-Uva, Mafalda; Gaio, Vania; Faustino, Paula; Nunes, Baltazar; Matias-Dias, Carlos; Barreto, MartaAims: Anemia is a global public health problemwith relevant adverse health, social and economic consequences. The objective of this study was to analyze the distribution of the prevalence of anemia in the Portuguese population. Methods: This is a cross-sectional population-based study, based on the first Portuguese National Health Examination Survey (INSEF), which included 4812 participants aged 25 to 74 years,...
Preliminary studies on the role of mazEF in S. epidermidis biofilms dormancy
Gaio, Vania; Cerca, Nuno; França, Ângela Maria Oliveira SousaBackground: Staphylococcus epidermidis has been recognized as one of the main causes of nosocomial infections, mainly due to its ubiquitous presence on human skin and mucous membranes and capacity to form biofilms on the surface of indwelling medical devices. S. epidermidis biofilm-associated infections are a major concern since biofilms present higher antimicrobial tolerance and ability to evade host immune de...
Genetic variation at the CYP2C19 gene associated with metabolic syndrome suscep...
Gaio, Vania; Nunes, Baltazar; Fernandes, Aida; Mendonça, Francisco; Horta Correia, Filomena; Beleza, Álvaro; Gil, Ana Paula; Bourbon, MafaldaBACKGROUND: Metabolic syndrome (MetS) is a cluster of conditions that occur together, increasing the risk of heart disease, stroke and diabetes. Since pathways implicated in different diseases reveal surprising insights into shared genetic bases underlying apparently unrelated traits, we hypothesize that there are common genetic components involved in the clustering of MetS traits. With the aim of identifying t...
Genetic variation at the CY2C19 gene associated with Metabolic Syndrome suscept...
Gaio, Vania; Nunes, Baltazar; Fernandes, Aida; Mendonça, Francisco; Horta Correia, Filomena; Beleza, Álvaro; Gil, Ana Paula; Bourbon, MafaldaMetabolic syndrome (MetS) is a cluster of conditions — increased blood pressure, high blood glucose level, excess body fat around the waist and abnormal cholesterol levels — that occur together, increasing the risk of heart disease, stroke and diabetes. In Portugal, the MetS prevalence is estimated to be 27,5% with regional variations, being highest in the Alentejo (30,99%) and lowest in the Algarve (24,42%), c...
Prevalence of diabetes-associated gene variants and its association with blood ...
Gaio, Vania; Fernandes, Aida; Mendonça, Francisco; Horta Correia, Filomena; Beleza, Álvaro; Gil, Ana Paula; Bourbon, Mafalda; Vicente, A.M.The global rise in incidence of type 2 (T2D) has been called a pandemic, constituting a major public health concern. Although environmental factors play a substantial role in the etiology of T2D, genetic susceptibility has been established as a key component in T2D risk. Given the absence of studies regarding the prevalence of T2D associated variants in the Portuguese population, our aim was to determine the pr...