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Minimum concentration of Amphotericin B in serum according to the formulation, ...
Schiave,Leticia Aparecida; Nascimento,Erika; Gaspar,Gilberto Gambero; Vilar,Fernando Crivelenti; Martinez,Edson Zangiacomi; Gaitani,Cristiane Masetto deAbstract INTRODUCTION: The therapeutic efficacy of daily amphotericin B infusion is related to its maximum concentration in blood; however, trough levels may be useful in intermittent regimens of this antifungal drug. METHODS : High performance liquid chromatography (HPLC) was used to determine the minimum concentration (Cmin) of amphotericin B in the serum of patients receiving deoxycholate (D-Amph) or liposom...
Fluconazole levels in serum and cerebrospinal fluid according to daily dosage i...
Schiave,Letícia Aparecida; Nascimento,Erika; Vilar,Fernando Crivelenti; de Haes,Tissiana Marques; Takayanagui,Osvaldo MassaitiABSTRACT Fluconazole is extensively used for the treatment of candidiasis and cryptococcosis. Among other factors, successful treatment is related to appropriate fluconazole levels in blood and cerebrospinal fluid. In the present study, fluconazole levels were determined in 15 patients, 14 of whom had AIDS and 13 had neurocryptococcosis. The only selection criterion was treatment with fluconazole, which was per...
Análise enantiosseletiva de fármacos: contribuições da cromatografia líquida de...
Bonato,Pierina Sueli; Jabor,Valquíria Aparecida Polisel; Gaitani,Cristiane Masetto deThe demand for analytical methods suitable for accurate and reproducible determination of drug enantiomers has increased significantly in the last years. High-performance liquid chromatography (HPLC) using chiral stationary phases and capillary electrophoresis (CE) are the most important techniques used for this purpose. In this paper, the fundamental aspects of chiral separations using both techniques are pres...