5 documents found, page 1 of 1
Glycoproteomics identifies HOMER3 as a potentially targetable biomarker trigger...
Peixoto, A; Ferreira, D; Azevedo, R; Freitas, R; Fernandes, E; Relvas-Santos, M; Gaiteiro, C; Soares, J; Cotton, S; Teixeira, B; Paulo, P; Lima, LBackground: Muscle invasive bladder cancer (MIBC) remains amongst the deadliest genitourinary malignancies due to treatment failure and extensive molecular heterogeneity, delaying effective targeted therapeutics. Hypoxia and nutrient deprivation, oversialylation and O-glycans shortening are salient features of aggressive tumours, creating cell surface glycoproteome fingerprints with theranostics potential. Meth...
Nucleolin-sle a glycoforms as E-selectin ligands and potentially targetable bio...
Fernandes, E; Freitas, R; Ferreira, D; Soares, J; Azevedo, R; Gaiteiro, C; Peixoto, A; Oliveira, S; Cotton, S; Relvas-Santos, M; Afonso, LP; Palmeira, CBackground: Gastric cancer (GC) is a major health burden worldwide, with half of patients developing metastases within 5 years after treatment, urging novel biomarkers for diagnosis and efficient therapeutic targeting. Sialyl-Lewis A (SLeA), a terminal glycoepitope of glycoproteins and glycolipids, offers tremendous potential towards this objective. It is rarely expressed in healthy tissues and blood cells, whi...
CD44 glycoprotein in cancer: A molecular conundrum hampering clinical applications
Azevedo, R; Gaiteiro, C; Peixoto, A; Relvas-Santos, M; Lima, L; Santos, L; Ferreira, JACD44 is a heavily glycosylated membrane receptor playing a key role in cell adhesion, signal transduction and cytoskeleton remodelling. It is also one of the most studied glycoproteins in cancer, frequently explored for stem cell identification, and associated with chemoresistance and metastasis. However, CD44 is a general designation for a large family of splicing variants exhibiting different degrees of glyco...
Mechanisms of cisplatin resistance and targeting of cancer stem cells: Adding g...
Ferreira, JA; Peixoto, A; Neves, M; Gaiteiro, C; Reis, CA; Assaraf, Y; Santos, LCisplatin-based chemotherapeutic regimens are the most frequently used (neo)adjuvant treatments for the majority of solid tumors. While platinum-based chemotherapeutic regimens have proven effective against highly proliferative malignant tumors, significant relapse and progression rates as well as decreased overall survival are still observed. Currently, it is known that sub-populations of chemoresistant cells ...
Transthyretin participates in beta-amyloid transport from the brain to the live...
Alemi, M; Gaiteiro, C; Ribeiro, C; Santos, L; Gomes, J; Oliveira, S; Couraud, P; Weksler, B; Romero, I; Saraiva, MJ; Cardoso, ITransthyretin (TTR) binds Aβ peptide, preventing its deposition and toxicity. TTR is decreased in Alzheimer’s disease (AD) patients. Additionally, AD transgenic mice with only one copy of the TTR gene show increased brain and plasma Aβ levels when compared to AD mice with both copies of the gene, suggesting TTR involvement in brain Aβ efflux and/or peripheral clearance. Here we showed that TTR promotes Aβ inter...