6 documents found, page 1 of 1
loysia citrodora extract as a chemopreventive agent against HPV16-induced lesio...
Medeiros-Fonseca, Beatriz; Faustino-Rocha, Ana I; Silva, Jessica; Pires, Maria João; Neuparth, Maria João; Vala, Helena; Vasconcelos-Nóbrega, CarmenAim: Aloysia citrodora has a long history of traditional use in treating various ailments. This study evaluated the in vivo chemopreventive efficacy and systemic toxicity of an extract of A. citrodora in a transgenic mouse model of HPV16 (human papillomavirus type 16)-induced cancer. Methods: The experiment involved six groups (n = 5): group 1 (G1, wild-type (WT), water), group 2 (G2, HPV, water), group 3 (G3, ...
Cumulus cell DNA damage linked to fertilization success in females with an ovul...
Rodrigues, B; Sousa, V; Esteves, F; Vale-Fernandes, E; Costa, S; Sousa, D; Brandão, R; Leal, C; Pires, J; Gaivão, I; Teixeira, JP; Nogueira, AJAIntracytoplasmic sperm injection (ICSI) is a widely used technique in fertility centers. ICSI success depends on both nuclear and cytoplasmic oocyte maturation. Cumulus cells, which surround the oocytes, play a pivotal role in oocyte competence. However, the significance of DNA damage in cumulus cells as a marker of fertilization success remains largely unexplored. This study aims to investigate the relationshi...
The red seaweed Grateloupia turuturu prevents epidermal dysplasia in HPV16-tran...
Almeida, J; Ferreira, T; Santos, S; Pires, MJ; Gil da Costa, RM; Medeiros, R; Bastos, MMSM; Neuparth, MJ; Faustino-Rocha, AI; Abreu, A; Pereira, RAbstract: The role of dietary profiles in promoting or reducing the risk of multiple types of cancer is increasingly clear, driving the search for balanced foods and nutraceuticals. The red seaweed Grateloupia turuturu has been used as human food showing a balanced nutritional profile. This study aims to test in vivo chemopreventive effects of G. turuturu against cutaneous pre-malignant lesions in transgenic mi...
Pulegone and Eugenol Oral Supplementation in Laboratory Animals: Results from A...
Ribeiro-Silva, CM; Faustino-Rocha, Ana I.; Gil da Costa, RM; Medeiros, R; Pires, MJ; Gaivão, I; Gama, A; Neuparth, MJ; Barbosa, JV; Peixoto, FEssential oils are natural compounds used by humans for scientific purposes due to their wide range of properties. Eugenol is mostly present in clove oil, while pulegone is the main constituent of pennyroyal oil. To guarantee the safe use of eugenol and pulegone for both humans and animals, this study addressed, for the first time, the effects of these compounds, at low doses (chronic toxicity) and high doses (...
Dietary supplementation with chestnut (Castanea sativa) reduces abdominal adipo...
Rodrigues, P; Ferreira, T; Nascimento-Gonçalves, E; Seixas, F; Costa, RMG; Martins, T; Neuparth, MJ; Pires, MJ; Lanzarin, G; Félix, LM; Venâncio, CThe production of chestnut (Castanea sativa Miller) is mostly concentrated in Europe. Chestnut is recognized by its high content of antioxidants and phytosterols. This work aimed to evaluate the effects of dietary chestnut consumption over physiological variables of FVB/n mice. Eighteen FVB/n male 7-month-old mice were randomly divided into three experimental groups (n = 6): 1 (control group) fed a standard die...
Ginkgo biloba L. Leaf Extract Protects HepG2 Cells Against Paraquat-Induced Oxi...
Silva, AM; Silva, SC; Soares, JP; Martins-Gomes, C; Teixeira, JP; Leal, F; Gaivão, IGinkgo biloba L. leaf extracts and herbal infusions are used worldwide due to the health benefits that are attributed to its use, including anti-neoplastic, anti-aging, neuro-protection, antioxidant and others. The aim of this study was to evaluate the effect of an aqueous Ginkgo biloba extract on HepG2 cell viability, genotoxicity and DNA protection against paraquat-induced oxidative damage. Exposure to paraqu...