129 documents found, page 1 of 13
Opioid detection and quantification in plasma and oral fluid by LC-MS/MS.
Rosendo, Luana M; Costa, Suzel; Simões, Susana; Franco, João; Serrano Gadea, Noelia; Escorial, Mónica; Toboso Ortega, Francisco JavierThe opioid crisis remains a significant public health concern, necessitating the development of sensitive and reliable analytical methods for drug detection. This study aimed to develop and validate a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous detection and quantification of fentanyl, buprenorphine, oxycodone, morphine, tramadol, and tapentadol in plasma and oral fluid...
Characterisation of the poisoning profile in the emergency department of Lamego...
Oliveira, Márcia; Gallardo, Eugenia; Fonseca, Cecília; Araújo, André R. T. S.Background: In clinical practice, the concept of poisoning refers to contact with substances that, depending on their physical and chemical properties, can disrupt the normal functioning of the body. Drug poisonings are becoming increasingly common and have become one of the most significant public health issues [1]. Objective: The main objective of this study was to characterize adult poisonings treated in the...
Characterization of Antidepressant Consumption in a Portuguese Inland Population.
Soares, Sofia; Rosado, Tiago; Santos, Vítor Hugo; Rei, Cristina; Amantegui, Patricia; Pissarra da Costa, António; Chaves, Telma; Valente, RitaMental disorders are a growing global concern, with depression being among the most prevalent. Portugal ranks second in antidepressant consumption within the OECD, following a threefold increase between 2000 and 2020. In inland regions such as Beira Interior, reduced healthcare services and distance from major hospitals further complicate access to care. This study analysed 142 patients from Beira Interior unde...
Determination of ketamine and norketamine in hair samples by µ-QuEChERS and gas...
Pelixo, Rodrigo; Barroso, Mário; Rosado, Tiago; Gallardo, EugeniaKetamine has gained popularity in Europe as a new psychoactive substance due to its dissociative effects, which are sought after by users at raves, for unprescribed treatment of psychological issues, and in drug-facilitated crimes. Forensic experts often face challenges in proving drug use, and hair offers distinct advantages as a sample, revealing both long-term consumption and recent abuse. However, due to it...
Chromatographic determination of antidepressants in plasma and saliva: Towards ...
Soares, Sofia; Rosendo, Luana; Fonseca, Suzana; Gonçalves, Nuno; Franco, João; da Costa, António Pissarra; Rosado, Tiago; Barroso, MárioDrug monitoring of antidepressants in plasma and oral fluid represents a valuable tool in clinical practice, enabling the optimisation of treatment efficacy and the reduction of adverse effects. Given the significant interindividual variability in antidepressant response-driven by factors such as metabolism, drug-drug interactions, and adherence to therapy-drug monitoring facilitates dose adjustment based on me...
Volumetric absorptive microsampling in toxicology
Pires, Bruno; Catarro, Gonçalo; Soares, Sofia; Gonçalves, Joana; Rosado, Tiago; Barroso, Mário; Araujo, André R T S; Gallardo, EugeniaVolumetric absorptive microsampling (VAMS) is an emerging technique in clinical and forensic toxicology. It is recognized as a promising alternative to traditional sampling methods, offering an accurate and minimally invasive means of collecting small volumes of biological samples, such as blood, urine, and saliva. Unlike conventional methods, VAMS provides advantages in terms of sample stability, storage, and ...
Advanced classification of Brazilian stingless bee honey by genus using compreh...
Ressutte, Jéssica; Galvan, Diego; Luz, Cynthia F.P. da; Gonçalves, Ana Margarida; Rebelo, Kemilla S.; Sattler, José Augusto G.; Passarinha, Luis A.This study aimed to investigate Brazilian stingless bee honey (SBH) to compare their chemical compositions. Fifty-five samples from the genera Melipona, Scaptotrigona, Frieseomelitta, Tetragona, and Tetragonisca, collected from five regions were evaluated by melissopalynological and physicochemical analysis, phenolic compounds, sugar profiling, and FTIR-ATR. Multiblock Analysis (MA) was employed to discriminate...
Valorization of fruit distillation pomaces
Serra, Lara; Pitacas, F.I.; Pedro, Soraia; Pires, Bruno; Fernandes, Tiago; Luís, Ângelo; Gallardo, Eugenia; Anjos, O.This study aims to characterise the nutritional composition of distillation pomace from the production of spirits from apple, pear and strawberry tree fruits (STFs) and to assess its potential for valorisation within circular economy and zero waste strategies. Pomace samples were collected after distillation at a distillery in Castelo Branco. Two batches per fruit type, each with three replicates, were analysed...
Production and Characterization of a Pullulan-Based Facial Mask Incorporating G...
Ferreira, Ester; Encarnação, Bárbara; Cascalheira, José Francisco; Ferreira, Susana; Ramos, Ana; Luís, Ângelo; Gallardo, Eugenia; Domingues, FernandaThis study aimed to develop and characterize an eco-friendly facial mask based on the pullulan biopolymer incorporating grape seed flour extract, a sustainable source of polyphenols. The extract was characterized by its phenolic content, antioxidant capacity, enzyme inhibition and antimicrobial activity. High total phenolic and flavonoid contents, along with the presence of -resveratrol, conferred strong antiox...
Bioactive Potential of Wild Plants from Gardunha Mountain: Phytochemical Charac...
Coimbra, Alexandra; Gallardo, Eugenia; Luís, Ângelo; Gaspar, Pedro Dinis; Ferreira, Susana; Duarte, Ana PaulaThe plants used in folk medicine have been increasingly studied to identify their bioactive properties. Therefore, this study aimed to assess the bioactivity of the hydroethanolic extracts of plants collected in Gardunha Mountain, Portugal. Seven abundant and representative wild plants were studied: , , , , , , and . The phytochemical composition of the extracts was determined by UHPLC-timsTOF-MS and by spectro...