20 documents found, page 1 of 2
meso-Dimethylaminonaphthyl-BODIPY Derivatives as Bioimaging Probes to Monitor I...
Gonçalves, Raquel C. R.; Pinto, Sónia C.S.; Teixeira, Filipe; Belmonte-Reche, Efres; da Silva, Milene Costa; Gallo, Juan; Costa, Susana P. G.Fluorescence-based probes are a powerful tool for monitoring living systems in real time with spatiotemporal precision. 3-Difluoroborodipyrromethene (BODIPY) derivatives are widely used as bioimaging probes due to their excellent photophysical properties, high quantum yields, and chemical stability. In this context, we report two BODIPY-based fluorescent probes for visualizing lysosomes and lipid droplets as we...
Enhanced alpha-amylase inhibition activity of amine-terminated PAMAM dendrimer ...
Jeevanandam, Jaison; Gonçalves, Mara; Castro, Rita; Gallo, Juan; Bañobre-López, Manuel; Rodrigues, João; Gonçalves, Mara; Castro, Rita; Rodrigues, JoãoThe present work aims to prepare copper-doped MgO nanoparticles via a sol-gel approach and study their antidiabetic alpha-amylase inhibition activity with undoped MgO nanoparticles. The ability of G5 amine terminated polyamidoamine (PAMAM) dendrimer for the controlled release of copper-doped MgO nano particles to exhibit alpha-amylase inhibition activity was also evaluated. The synthesis of MgO nanoparticles vi...
Magnetic solid nanoparticles and their counterparts: recent advances towards ca...
Cerqueira, Mónica; Belmonte-Reche, Efres; Gallo, Juan; Baltazar, Fátima; Bañobre-López, ManuelCancer is currently a leading cause of death worldwide. The World Health Organization estimates an increase of 60% in the global cancer incidence in the next two decades. The inefficiency of the currently available therapies has prompted an urgent effort to develop new strategies that enable early diagnosis and improve response to treatment. Nanomedicine formulations can improve the pharmacokinetics and pharmac...
Graphene-based magnetic nanoparticles for theranostics: an overview for their p...
Lage, Teresa Cristina Carqueijó; Rodrigues, Raquel Oliveira; Catarino, Susana Oliveira; Gallo, Juan; Bañobre-López, Manuel; Minas, GraçaThe combination of diagnostics and therapy (theranostic) is one of the most complex, yet promising strategies envisioned for nanoengineered multifunctional systems in nanomedicine. From the various multimodal nanosystems proposed, a number of works have established the potential of Graphene-based Magnetic Nanoparticles (GbMNPs) as theranostic platforms. This magnetic nanosystem combines the excellent magnetic p...
Magnetic dehydrodipeptide-based self-assembled hydrogels for theragnostic appli...
Carvalho, André; Gallo, Juan; Pereira, David M.; Valentão, Patrícia; Andrade, Paula B.; Hilliou, L.; Ferreira, Paula M. T.; Bañobre-López, ManuelSelf-assembled peptide hydrogels have emerged in recent years as the new paradigm in biomaterials research. We have contributed to this field the development of hydrogels based on dehydrodipeptides <i>N</i>-capped with naproxen. The dehydrodipeptide hydrogels can be loaded with drugs, thus being potential nanocarriers for drug delivery. In this work novel dehydrodipeptides containing tyrosine and aspartic acid ...
Synthesis, characterization and in vitro validation of a magnetic zeolite nanoc...
Vilaça, Natália; Gallo, Juan; Fernandes, Rui; Figueiredo, Francisco; Fonseca, António; Baltazar, Fátima; Neves, Isabel C.; Bañobre-López, ManuelMagnetic nanoparticles (MNPs) have been gaining significant importance as building blocks to form more complex nanostructures due to the multifunctional performance enabled by their magnetic character, i.e. in magnetic resonance imaging (MRI) and magnetic hyperthermia (MH). This study focusses on the development of a magnetic zeolite nanocomposite (MZNC) as a suitable platform towards the design of a theranosti...
Multifunctional graphene-based magnetic nanocarriers for combined hyperthermia ...
Rodrigues, Raquel Oliveira; Baldi, Giovanni; Doumett, Saer; Garcia-Hevia, Lorena; Gallo, Juan; Bañobre-López, Manuel; Dražić, GoranThe synthesis of hydrophilic graphene-based yolk-shell magnetic nanoparticles functionalized with copolymer pluronic F-127 (GYSMNP@PF127) is herein reported to achieve an efficient multifunctional biomedical system for mild hyperthermia and stimuli-responsive drug delivery. In vitro tests revealed the extraordinary ability of GYSMNP@PF127 to act as smart stimuli-responsive multifunctional nanomedicine platform fo...
Enhanced performance of cobalt ferrite encapsulated in graphitic shell by means...
Ribeiro, Rui; Gallo, Juan; Bañobre-López, Manuel; Silva, Adrián; Faria, Joaquim; Gomes, HelderHere we report preliminary catalytic wet peroxide oxidation (CWPO) experiments performed in the presence of an alternating current (AC) magnetic field. One ferromagnetic graphitic nanocomposite – composed by a cobalt ferrite core and a graphitic shell (CoFe2O4/MGNC), was employed in the process, here named magnetically activated catalytic wet peroxide oxidation (MA-CWPO). An aqueous solution containing 5.0 g L−...
A Tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanopar...
Rodrigues, Raquel Oliveira; Baldi, Giovanni; Doumett, Saer; Gallo, Juan; Bañobre-López, Manuel; Dražić, Goran; Calhelha, Ricardo C.A simple tailor-made protocol to synthesize graphene-based magnetic nanoparticles (GbMNPs) for nanomedicine is herein reported. Different GbMNPs with very distinctive physicochemical and toxicological properties were synthesized by adjusting the number of carbon precursors in the coating of superparamagnetic iron oxide nanoparticles. In vitro tests show the ability to use these GbMNPs as intelligent and on-dema...
A tailor-made protocol to synthesize yolk-shell graphene-based magnetic nanopar...
Rodrigues, Raquel O.; Baldi, Giovanni; Doumett, Saer; Gallo, Juan; Bañobre-López, Manuel; Dražić, Goran; Calhelha, Ricardo C.; Ferreira, Isabel C. F. R.A simple tailor-made protocol to synthesize graphene-based magnetic nanoparticles (GbMNPs) for nanomedicine is herein reported. Different GbMNPs with very distinctive physicochemical and toxicological properties were synthesized by adjusting the number of carbon precursors in the coating of superparamagnetic iron oxide nanoparticles. In vitro tests show the ability to use these GbMNPs as intelligent and on-dema...