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Evaluation of the cervicovaginal environment in asymptomatic Human T-cell lymph...

Firmino,Alisson de Aquino; Martins,Adenilda Lima Lopes; Gois,Luana Leandro; Paixão,Taiane Silva; Batista,Everton da Silva; Galvão-Castro,Bernardo

ABSTRACT Introduction: Human T-cell lymphotropic virus type 1 (HTLV-1) is sexually transmitted and causes persistent infection. This virus induces activation of the immune system and production of inflammatory cytokines. This study aimed to assess the cytokine profile and cytopathological findings in the cervicovaginal fluid of asymptomatic HTLV-1-infected women. Methods: HTLV-1-infected and uninfected women we...

Data: 2019   |   Origem: Oasisbr

Revisiting Keratoconjunctivitis sicca associated with Human T-Cell Lymphotropic...

Rathsam-Pinheiro,Regina Helena; Boa-Sorte,Ney; Grassi,Maria Fernanda Rios; Copello,Úrsula Cury; Rios,Karla Tayrine Silva Guimarães; Araújo,Thessika

ABSTRACT Background: The prevalence of keratoconjunctivitis sicca (KCS) associated with Human T-Cell Lymphotropic Virus Type 1 (HTLV-1) (HTLV-1/KCS) has been estimated at around 37%, but its clinical manifestations are poorly described. Purpose: To determine the prevalence and associated factors of HTLV-1/KCS in a large cohort of HTLV-1-infected individuals living in Salvador, Brazil. Methods: A cross-sectional...

Data: 2019   |   Origem: Oasisbr

Algorithm for dry eye disease diagnosis in individuals infected with human T-ce...

Castro-Lima-Vargens,Cristina; Grassi,Maria Fernanda Rios; Boa-Sorte,Ney; Rathsam-Pinheiro,Regina Helena; Almeida,Paula Caroline Matos

ABSTRACT Purpose: To evaluate the accuracy of lacrimal film tests and propose an algorithm for the diagnosis of dry eye disease in individuals infected with human T-cell lymphotropic virus type 1. Methods: Ninety-six patients infected with human T-cell lymphotropic virus type 1 were enrolled in the study. To assess clinical complaints, patients completed the Ocular Surface Disease Index questionnaire. To evalua...

Data: 2017   |   Origem: Oasisbr

Completeness of tuberculosis reporting forms for disease control in individuals...

Lírio,Monique; Santos,Normeide Pedreira dos; Passos,Louran Andrade Reis; Kritski,Afrânio; Galvão-Castro,Bernardo; Grassi,Maria Fernanda Rios

The control of HIV / Tuberculosis (TB) co -infection remains a challenge for public health. Notification is mandatory for both diseases and the National Case Registry Database (Sinan) is responsible for the collection and processing of individual forms of reporting and monitoring. The adequate fulfillment of these fields chips (completeness) is essential to follow the dynamics of the disease and set priorities ...

Data: 2015   |   Origem: Oasisbr

Sickle cell disease retinopathy: characterization among pediatric and teenage p...

Oliveira,Dayse Cury de Almeida; Carvalho,Magda O.S.; Nascimento,Valma Maria Lopes do; Villas-Bôas,Flávia Silva; Galvão-Castro,Bernardo

Objective: The aim of the present study was to characterize sickle cell disease retinopathy in children and teenagers from Bahia, the state in northeastern Brazil with the highest incidence and prevalence of sickle cell disease. Methods: A group of 51 sickle cell disease patients (36 hemoglobin SS and 15 hemoglobin SC) with ages ranging from 4 to 18 years was studied. Ophthalmological examinations were performe...

Data: 2014   |   Origem: Oasisbr

Dried blood spot testing for the antenatal screening of HTLV, HIV, syphilis, to...

Boa-Sorte,Ney; Purificação,Antônio; Amorim,Tatiana; Assunção,Lorena; Reis,Alan; Galvão-Castro,Bernardo

Introduction:Screening for vertically transmitted infection is mandatory and must be conducted at the first prenatal consultation. The most vulnerable women's groups are those at the lowest socio-economic level. Dried blood spot testing on filter paper could represent a secure way to screen pregnant women in the prenatal period.Methods:A cross-sectional study was conducted between November 2009 and March 2010, ...

Data: 2014   |   Origem: Oasisbr

Evidence of a higher prevalence of HPV infection in HTLV-1-infected women: a cr...

Lôpo,Sônia Sampaio; Oliveira,Paula Matos; Santana,Iuri Usêda; Pena,Geisa Barbosa; Torrales,Maria Betânia; Mascarenhas,Rita Elizabeth

INTRODUCTION:HTLV-1 infection increases susceptibility to other infections. Few studies have addressed the co-infection between HPV and HTLV-1 and the immune response involved in this interaction. The aim of this study was to determine the prevalence of cervical HPV infection in HTLV-1-infected women and to establish the risk factors involved in this co-infection. METHODS: A cross-sectional study was carried ou...

Data: 2012   |   Origem: Oasisbr

Evolution of HTLV-1 proviral load in patients from Salvador, Brazil

Olavarria,Viviana Nilla; Gomes,Alline do Nascimento; Kruschewsky,Ramon de Almeida; Galvão-Castro,Bernardo; Grassi,Maria Fernanda Rios

INTRODUCTION: Variations in human T cell lymphotropic virus type 1 (HTLV-1) proviral load (PVL) in infected individuals over time are not well understood. Objective: To evaluate the evolution of proviral load in asymptomatic individuals and HAM/TSP patients in order to help determine periodicity for measuring proviral load. METHODS: A group of 104 HTLV-1 infected patients, followed at the HTLV reference center ...

Data: 2012   |   Origem: Oasisbr

Ocular lesions in sickle cell disease patients from Bahia, Brazil

Cury,Dayse; Boa-Sorte,Ney; Lyra,Isa Menezes; Zanette,Angela Dias; Castro-Lima,Humberto; Galvão-Castro,Bernardo; Gonçalves,Marilda Souza

OBJECTIVE: The present study aims to describe ocular alterations in sickle cell disease patients in Bahia, a Northeast state, with the highest prevalence of the disease in Brazil. METHODS: We carried out a cross-sectional study in a group of 146 (292 eyes) sickle cell disease patients (90 HBSS and 56 HBSC). Ophthalmologic examination including indirect binocular ophthalmoscopy was performed. Examination was com...

Data: 2010   |   Origem: Oasisbr

HLA-Bw4-B*57 and Cw*18 alleles are associated with plasma viral load modulation...

Silva,Edinete Melo da; Acosta,Angelina Xavier; Santos,Eduardo José Melo; Netto,Eduardo Martins; Lemaire,Denise Carneiro; Oliveira,Adriano Silva

Host genetic factors play an important role in mediating resistance to HIV-1 infection and may modify the course of infection. HLA-B alleles (Bw4 epitope; B*27 and B*57) as well as killer cell immunoglobulin-like receptors have been associated with slow progression of HIV-1 infection. OBJECTIVE: To evaluate the association between serological epitopes HLA-Bw4 and HLA-Bw6 and prognostic markers in AIDS. METHODS:...

Data: 2010   |   Origem: Oasisbr

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