51 documents found, page 1 of 6
The role of natural compounds in rat mammary cancer: the beneficial effects of ...
Azevedo, Tiago; Silva, Jessica; Peixoto, Francisco P.; Silvestre-Ferreira, Ana C.; Gama, Adelina; Seixas, Fernanda; Finimundy, Tiane C.; Barros, LillianBreast cancer is the most diagnosed cancer among women, and a leading cause of death worldwide. Santolina chamaecyparissus L. is a plant with multiple health benefits, including anticancer and anti-diabetic properties. This study aimed to assess the chemopreventive effects of S. chamaecyparissus aqueous extract (SCE) in an animal model of mammary cancer. A total of 28 four-week-old female Wistar rats were divid...
Neurological lesions in cervids: a study in Portugal
Pires, Maria A.; Macêdo, J.; Seixas, Fernanda; Gama, Adelina; Alves, Anabela; Pinto, Maria de Lurdes; Pires, Isabel; Matos, Ana Cristina; Figueira, LuisBrain samples were collected within the project "CWD Risk in Portugal", profiOng the infecOous diseases epidemiological surveillance and screening of chronic wasOng disease (CWD) during cervids hunts. The literature on wild animals´ neuropathological lesions is scarse. This work aims to describe the neuropathological findings in samples collected in deer hunted in Portugal.
Cytinus hypocistis (L.) L. extract effects in an animal model of papillomavirus...
Medeiros, Catarina; Silva, Ana Rita; Ferreira, Tiago; Barros, Lillian; Neuparth, Maria João; Peixoto, Francisco P.; Bastos, Margarida M.S.M.Infections with certain types of papillomavirus, such as the human papillomavirus 16 (HPV16), are associated with the development of preneoplastic lesions and cancers of the anogenital, and head and neck regions. Cytinus hypocistis (L.) L. extracts are composed of substances presenting antiproliferative, antioxidant, anti-inflammatory and antibacterial properties, which might be promising as new therapeutic com...
Estimating sequence diversity of prion protein gene (PRNP) in Portuguese popula...
Pereira, Jorge C.; Gonçalves-Anjo, Nuno; Orge, Leonor; Pires, Maria dos Anjos; Rocha, Sara; Figueira, Luís; Matos, Ana Cristina; Silva, JoãoAmong the transmissible spongiform encephalopathies (TSEs), chronic wasting disease (CWD) in cervids is now a rising concern in wildlife within Europe, after the detection of the first case in Norway in 2016, in a wild reindeer and until June 2022 a total of 34 cases were described in Norway, Sweden and Finland. The definite diagnosis is post-mortem, performed in target areas of the brain and lymph nodes. Sampl...
Animal models of colorectal cancer: from spontaneous to genetically engineered ...
Nascimento-Gonçalves, Elisabete; Mendes, Bruno; Silva-Reis, Rita; Faustino-Rocha, Ana Isabel; Gama, Adelina; Oliveira, Paula AlexandraColorectal cancer is one of the most common gastrointestinal malignancies in humans, affecting approximately 1.8 million people worldwide. This disease has a major social impact and high treatment costs. Animal models allow us to understand and follow the colon cancer progression; thus, in vivo studies are essential to improve and discover new ways of prevention and treatment. Dietary natural products have been...
Refinement of animal model of colorectal carcinogenesis through the definition ...
Silva-Reis, Rita; Faustino-Rocha, Ana Isabel; Gonçalves, Mariana; Castro Ribeiro, Catarina; Ferreira, Tiago; Ribeiro-Silva, Carla; Gonçalves, LioThis study aimed to define appropriate humane endpoints (HEs) for an animal model of colorectal carcinogenesis (CRC). Twenty-nine male Wistar rats were divided into two control groups (CTRL1 and CTRL2) injected with ethylenediamine tetraacetic acid (EDTA)–saline solutions and two induced groups (CRC1 and CRC2) injected with 1,2-dimethylhydrazine (DMH) for seven weeks. A score sheet with 14 biological parameters...
Pre-neoplastic lesions associated with liver and colon responses to 1,2-dimethy...
Silva-Reis, Rita; Faustino-Rocha, Ana Isabel; Castro-Ribeiro, Carla; Gonçalves, Mariana; Ferreira, Tiago; Gama, Adelina; Ferreira, RitaBackground: The high incidence and mortality of colorectal cancer (CRC) combined with the lack of an effective method for early diagnosis and effective treatments make CRC one of the most relevant cancers to be studied. Thus, our work aims to study the spectrum of liver and colon lesions induced in rats by the 1,2-Dimethylhydrazine (DMH). Materials and Methods: Twenty-nine male Wistar rats were randomly divided...
Immunology and mammary cancer development: addressing the role of mast cells
Faustino-Rocha, Ana Isabel; Oliveira, Paula Alexandra; Gama, Adelina; Ferreira, Rita; Ginja, MárioBackground: Mammary cancer is one of the most frequent cancers worldwide. Mast cells are among the cells of tumor microenvironment and have been associated with increased angiogenesis and poor prognosis. Despite this, the role of mast cells on mammary cancer is not fully elucidated. In this way, this work studied the role of mast cells in a rat model of mammary cancer chemically-induced. Materials and Methods: ...
Interaction between intense pulsed light and skin: data from an animal model
Faustino-Rocha, Ana Isabel; Ferreira, Rita; Pires, Maria João; Gama, Adelina; Oliveira, Paula AlexandraBackground: Although its effects remain unknown, the intense pulsed light (IPL) has been extensively used in dermatology and esthetics. Purpose: This study aimed to address the impact of IPL in neoplastic lesions using an animal model. Methodology: All experiments followed the European and National legislation. Sixteen ICR female DBA/2JRccHsd mice were randomly assessed to two experimental groups: IPL-exposed (...
Pre-neoplastic lesions associated with liver and colon responses to 1,2-dimethy...
Silva-Reis, Rita; Faustino-Rocha, Ana Isabel; Castro-Ribeiro, Carla; Gonçalves, Mariana; Ferreira, Tiago; Gama, Adelina; Ferreira, RitaBackground: The high incidence and mortality of colorectal cancer (CRC) combined with the lack of an effective method for early diagnosis and effective treatments make CRC one of the most relevant cancers to be studied. Thus, our work aims to study the spectrum of liver and colon lesions induced in rats by the 1,2-Dimethylhydrazine (DMH). Materials and methods: Twenty-nine male Wistar rats were randomly divided...