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The roles of vitamin d and cathelicidin in type 1 diabetes susceptibility
Cristelo, C; Machado, A; Sarmento, B; Gama, FMType 1 diabetes has an increasingly greater incidence and prevalence with no cure available. Vitamin D supplementation is well documented to reduce the risk of developing type 1 diabetes. Being involved in the modulation of cathelicidin expression, the question whether cathelicidin may be one of the underlying cause arises. Cathelicidin has been implicated in both the development and the protection against type...
In vivo systemic toxicity assessment of an oxidized dextrin-based hydrogel and ...
Pereira, I; Fraga, S; Maltez, L; Requicha, J; Guardão, L; Oliveira, J; Prada, J; Alves, H; Santos, JD; Teixeira, JP; Pereira, JE; Soares, R; Gama, FMThe worldwide incidence of bone disorders is raising, mainly due to aging population. The lack of effective treatments is pushing the development of synthetic bone substitutes (SBSs). Most ceramic-based SBSs commercially available display limited handling properties. Attempting to solve these issues and achieve wider acceptance by the clinicians, granular ceramics have been associated with hydrogels (HGs) to pr...
Inhalation of Bacterial Cellulose Nanofibrils triggers an inflammatory response...
Silva-Carvalho, R; Silva, JP; Ferreirinha, P; Leitão, AF; Andrade, FK; Costa, RMG; Cristelo, C; Rosa, MF; Vilanova, M; Gama, FMIn view of the growing industrial use of Bacterial cellulose (BC), and taking into account that it might become airborne and be inhaled after industrial processing, assessing its potential pulmonary toxic effects assumes high relevance. In this work, the murine model was used to assess the effects of exposure to respirable BC nanofibrils (nBC), obtained by disintegration of BC produced by Komagataeibacter hanse...