14 documents found, page 1 of 2
Optimizing bacterial nanocellulose production from eucalyptus bark: A circular ...
Rodrigues, Ana Cristina; Martins, Daniela; Duarte, Maria Salomé; Marques, Susana; Gama, Miguel; Dourado, Fernando; Carvalho, Ricardo; Cavaleiro, AnaABSTRACT: The production cost of bacterial nanocellulose (BNC) is a major limitation to its widespread use. However, this limitation can be addressed by using alternative low-cost substrates and high-yield strains. Agro-industrial wastederived substrates offer a cost-effective and sustainable solution, but their high organic load often requires additional downstream wastewater treatments. Here, we optimized sta...
Randomized clinical study of injectable dextrin-based hydrogel as a carrier of ...
Machado, Alexandra; Pereira, Isabel; Costa, Filomena; Brandão, Ana; Pereira, José Eduardo; Maurício, Ana Colette; Santos, José Domingos; Amaro, InêsObjectives This study aimed to improve the performance and mode of administration of a glass-reinforced hydroxyapatite synthetic bone substitute, Bonelike by Biosckin® (BL®), by association with a dextrin-based hydrogel, DEXGEL, to achieve an injectable and moldable device named DEXGEL Bone. Methods Twelve participants requiring pre-molar tooth extraction and implant placement were enrolled in this study. BL® g...
Bacterial nanocellulose membrane as novel substrate for biomimetic structural c...
Suleimenova, Akmaral; Frasco, Manuela F.; Soares da Silva, Francisco A.G.; Gama, Miguel; Fortunato, Elvira; Sales, M. Goreti F.The development of optical biosensors based on structural colors generated by short-range ordered colloidal particles is attracting growing interest due to their non-iridescent and non-fading features. In this study, a biomimetic approach using biopolymers for the various steps of sensor construction is presented. Bacterial nanocellulose (BNC) has many foreseen applications in biomedical engineering because of ...
Dextrin hydrogel loaded with a macroporous Bonelike® scaffold and dental pulp s...
Machado, Alexandra; Pereira, Isabel; Pereira, José Eduardo; Maltez, Luís; Brandão, Ana; Alvites, Rui; Sousa, Ana Catarina; Branquinho, MarianaRegeneration of severe bone defects remains a challenge. A formulation of synthetic glass-reinforced hydroxyapatite bone substitute, Bonelike® Poro (BL®P), 250–500 µm-diameter, with a dextrin-based hydrogel (HG), further loaded with human dental pulp stem cells (hDPSCs) with osteogenic differentiation ability, was tested for the management of critical-sized defects in an ovine model. Morphology, calcium release...
Performance of bacterial nanocellulose packaging film functionalised in situ wi...
Silva, Francisco A. G. Soares; Carvalho, Teresa Bento de; Dourado, Fernando; Gama, Miguel; Teixeira, Paula; Poças, FátimaZinc oxide nanoparticles (ZnO) are cost-effective antimicrobial agents with great potential for the active packaging industry. Bacterial NanoCellulose (BNC) features a porous fibre network, with high absorption capacity, flexible and with good mechanical properties, suitable as a carrier of active agents. In this work, BNCZnO films were developed and optimized regarding the particle size and ZnO concentration. ...
Antimicrobial activity of in-situ bacterial nanocellulose-zinc oxide composites...
Silva, Francisco A. G. Soares; Carvalho, Marta; Carvalho, Teresa Bento de; Gama, Miguel; Poças, Fátima; Teixeira, PaulaActive substances such as zinc oxide nanoparticles (ZnO) have been extensively explored due to their antimicrobial properties, low cost and scalability. Yet, their effectiveness is highly dependent on their morphology and specific surface area. Bacterial nanocellulose (BNC) is a suitable carrier due to its ability to transport and deliver active substances. In the case of nanocellulose-ZnO composites, conclusio...
Nanocellulose bio-based composites for food packaging
Silva, Francisco A. G. S.; Dourado, Fernando; Gama, Miguel; Fátima PoçasThe food industry is increasingly demanding advanced and eco-friendly sustainable packaging materials with improved physical, mechanical and barrier properties. The currently used materials are synthetic and non-degradable, therefore raising environmental concerns. Consequently, research efforts have been made in recent years towards the development of bio-based sustainable packaging materials. In this review, ...
In vitro genotoxicity assessment of an oxidized dextrin-based hydrogel for biom...
Pereira, Isabel; Fraga, Sónia; Silva, Susana; Teixeira, João Paulo; Gama, MiguelHydrogels are three‐dimensional, crosslinked networks of hydrophilic polymers swollen with a large amount of water or biological fluids, without dissolving. Dextrin, a low‐molecular‐weight carbohydrate composed by glucose residues, has been used to develop an injectable hydrogel for biomedical applications. Dextrin was first oxidized to introduce aldehyde groups, which then reticulate with adipic acid dihydrazi...
Effects of gamma irradiation and periodate oxidation on the structure of dextri...
Pereira, Isabel; Simões, Joana; Evtyugin, Dmitry V.; Rouif, Sophie; Coimbra, Manuel A.; Domingues, M. Rosário M.; Gama, MiguelSterilization of biomaterials by gamma irradiation should not change its structure, since this may affect also its bioactivity. In this work, dextrin and periodate-oxidized dextrin (ODEX), both irradiated and non-irradiated, were hydrolysed by α-amylase and the obtained oligosaccharides were fractionated by ligand-exchange/size exclusion chromatography and analyzed by matrix-assisted laser desorption/ionization...
Biomass saccharification : development of strategies for enzyme recycling
Rodrigues, Ana Cristina Costa; Haven, Mai Østergaard; Lindedam, Jane; Felby, Claus; Gama, MiguelIn the present work the recycling of free enzymes after prehydrolysis and simultaneous saccharification and fermentation of pretreated wheat straw under a variety of conditions was investigated. It was found that a significant amount of active cellulase and glucosidase could be recovered by recycling the free cellulases the amount of free enzymes increase with its thermostability and hydrolytic efficiency. At 5...