3 documents found, page 1 of 1
THE IMPACT OF NEUTROPHIL-TOLYMPHOCYTE RATIO AND PLATELETTO- LYMPHOCYTE RATIO IN...
Pereira-Neves, António; Fragão-Marques, Mariana; Rocha-Neves, João; Gamas, Luís; Oliveira-Pinto, José; Cerqueira, Alfredo; Andrade, JoséIntroduction: Inflammation is a common underlying feature of atherosclerosis. Several inflammatory biomarkers have been reported to have prognostic value, in several areas, including in vascular surgery. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) may permit to identify patients at greater risk for cerebrovascular events, tailor patient management, improve preoperative status...
Methylglyoxal-induced glycation changes adipose tissue vascular architecture, f...
Rodrigues, Tiago; Matafome, Paulo N.; Sereno, José; Almeida, José; Castelhano, João; Gamas, Luís; Neves, Christian; Gonçalves, Sónia; Carvalho, CatarinaMicrovascular dysfunction has been suggested to trigger adipose tissue dysfunction in obesity. This study investigates the hypothesis that glycation impairs microvascular architecture and expandability with an impact on insulin signalling. Animal models supplemented with methylglyoxal (MG), maintained with a high-fat diet (HFD) or both (HFDMG) were studied for periepididymal adipose (pEAT) tissue hypoxia and lo...
Irisin and Myonectin Regulation in the Insulin Resistant Muscle: Implications t...
Gamas, Luís; Matafome, Paulo N.; Seiça, RaquelMyokines are peptides produced and secreted by the skeletal muscle, with autocrine, paracrine, and endocrine actions. Many of them are overexpressed during physical exercise and appear to contribute to the benefits of exercise to metabolic homeostasis. Irisin, resulting from the cleavage of the membrane protein FNDC5, was shown to induce adipocyte browning, with increased lipid oxidation and thermogenesis. Myon...