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The Effect of Preoperative Chemotherapy Treatment in Surgically Treated Intrahe...

Buettner, S; Koerkamp, BG; Ejaz, A; Buisman, FE; Kim, Y; Margonis, GA; Alexandrescu, S; Pinto Marques, H; Lamelas, J; Aldrighetti, L; Gamblin, TC

INTRODUCTION: While preoperative chemotherapy (pCT) is utilized in many intra-abdominal cancers, the use of pCT among patients with intrahepatic cholangiocarcinoma (ICC) remains ill defined. As such, the objective of the current study was to examine the impact of pCT among patients undergoing curative-intent resection for ICC. METHODS: Patients who underwent hepatectomy for ICC were identified from a multi-inst...


Performance of Prognostic Scores and Staging Systems in Predicting Long-Term Su...

Buettner, S; Galjart, B; van Vugt, JL; Bagante, F; Alexandrescu, S; Pinto Marques, H; Lamelas, J; Aldrighetti, L; Gamblin, TC; Maithel, SK; Pulitano, C

INTRODUCTION: We sought to validate the commonly used prognostic models and staging systems for intrahepatic cholangiocarcinoma (ICC) in a large multi-center patient cohort. METHODS: The overall (OS) and disease free survival (DFS) prognostic discriminatory ability of various commonly used models were assessed in a large retrospective cohort. Harrell's concordance index (c-index) was used to determine accuracy ...


A Multi-Institutional Analysis of Elderly Patients Undergoing a Liver Resection...

Vitale, A; Spolverato, G; Bagante, F; Gani, F; Popescu, I; Pinto Marques, H; Aldrighetti, L; Gamblin, TC; Maithel, S; Sandroussi, C; Bauer, T; Shen, F

BACKGROUND: Little is known regarding postoperative outcomes of elderly patients undergoing liver surgery for intrahepatic cholangiocarcinoma (ICC). METHODS: Five hundred and eighty-four patients undergoing liver resection for ICC between 1990 and 2015 were identified. Perioperative morbidity, mortality, overall survival (OS), and disease-free survival (DFS) were compared between elderly (>70 year, n = 129) and...


The Role of Liver-Directed Surgery in Patients With Hepatic Metastasis From Pri...

Margonis, GA; Buettner, S; Sasaki, K; Kim, Y; Ratti, F; Russolillo, N; Ferrero, A; Berger, N; Gamblin, TC; Poultsides, G; Tran, T; Postlewait, LM

BACKGROUND: Data on surgical management of breast liver metastasis are limited. We sought to determine the safety and long-term outcome of patients undergoing hepatic resection of breast cancer liver metastases (BCLM). METHODS: Using a multi-institutional, international database, 131 patients who underwent surgery for BCLM between 1980 and 2014 were identified. Clinicopathologic and outcome data were collected ...


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