15 documents found, page 1 of 2
Improving feline mammary carcinoma treatment through HER2-related immunochemoth...
Gameiro, AndreiaABSTRACT - Improving feline mammary carcinoma treatment through HER2-related immunochemotherapy agents and biomarkers - The feline mammary carcinoma (FMC) is a common tumour, with the HER2-positive and triple-negative being the most aggressive subtypes, as in women. This tumour is usually diagnosed belatedly, with scarce information about its development, and limited therapeutic options beyond mastectomy, prese...
Análise de imagens de tomografia computorizada para determinação da área de sup...
Gameiro, AndreiaEm medicina veterinária, o cálculo das doses de fármacos aplicados em protocolos de quimioterapia está dependente da área de superfície corporal (ASC), considerando esta o peso, como a única variável morfométrica, introduzindo um fator de erro. Assim, este estudo visa determinar a ASC de cães (n=6), através de imagens de tomografia computorizada (TC) e, comparar à fórmula de cálculo em uso (Meeh, 1879) e a dete...
HER2-Targeted immunotherapy and combined protocols showed promising antiprolife...
Gameiro, Andreia; Nascimento, Catarina; Correia, Jorge Manuel de Jesus; Ferreira, FernandoABSTRACT - Feline mammary carcinoma (FMC) is a highly prevalent tumor, showing aggressive clinicopathological features, with HER2-positive being the most frequent subtype. While, in human breast cancer, the use of anti-HER2 monoclonal antibodies (mAbs) is common, acting by blocking the extracellular domain (ECD) of the HER2 protein and by inducing cell apoptosis, scarce information is available on use these imm...
Serum and tissue expression levels of leptin and leptin receptor are putative m...
Gameiro, Andreia; Nascimento, Catarina; Urbano, Ana Catarina; Correia, Jorge Manuel de Jesus; Ferreira, FernandoABSTRACT - Obesity is an established risk factor for breast cancer in post-menopausal women, being associated with elevated serum levels of leptin. Although overweight is a common condition in cat, the role of leptin and its receptor in feline mammary carcinoma remains unsettled. In this study, serum leptin and leptin receptor (ObR) levels were investigated in 58 cats with mammary carcinoma and compared with th...
Tyrosine kinase inhibitors are promising therapeutic tools for cats with HER2-p...
Gameiro, Andreia; Almeida, Filipe; Nascimento, Catarina; Correia, Jorge Manuel de Jesus; Ferreira, FernandoABSTRACT - Feline mammary carcinoma (FMC) is a common neoplasia in cat, being HER2-positive the most prevalent subtype. In woman’s breast cancer, tyrosine kinase inhibitors (TKi) are used as a therapeutic option, by blocking the phosphorylation of the HER2 tyrosine kinase domain. Moreover, clinical trials demonstrated that TKi produce synergistic antiproliferative effects in combination with mTOR inhibitors, ov...
Histone deacetylase inhibitors and microtubule inhibitors induce apoptosis in f...
Almeida, Filipe; Gameiro, Andreia; Correia, Jorge Manuel de Jesus; Ferreira, FernandoSimple Summary: Feline mammary tumors (FMT) are very common in cats, associated with very aggressive behavior and a short life expectancy. Surgery is the most used treatment but tumor recurrence is common. Currently, available therapies are insufficient, therefore, new molecular targets are needed to develop more efficient therapeutics. Histone deacetylases inhibitors (HDACis) have been developed to target tumo...
Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in feline mammary carcinoma
Nascimento, Catarina; Gameiro, Andreia; Ferreira, Fernando; Correia, Jorge Manuel de Jesus; Ferreira, JoãoVascular endothelial growth factor (VEGF-A) plays an essential role in tumor-associated angiogenesis, exerting its biological activity by binding and activating membrane receptors, as vascular endothelial growth factor receptor 1 and 2 (VEGFR-1, VEGFR-2). In this study, serum VEGF-A, VEGFR1, and VEGFR-2 levels were quantified in 50 cats with mammary carcinoma and 14 healthy controls. The expression of these mol...
VISTA is a diagnostic biomarker and immunotherapy target of aggressive feline m...
Gameiro, Andreia; Nascimento, Catarina; Correia, Jorge; Ferreira, FernandoABSTRACT - Feline mammary carcinoma (FMC) is a common neoplasia, showing aggressive clinicopathological features, without viable therapeutic options. The study of tumor microenvironment has gained importance, due to the ability to control tumor progression by regulating the immune response. Considering the lack of knowledge, feline serum VISTA levels from cats with mammary carcinoma were compared with healthy c...
Emerging biomarkers and targeted therapies in feline mammary carcinoma
Gameiro, Andreia; Urbano, Ana Catarina; Ferreira, FernandoABSTRACT - : Feline mammary carcinoma (FMC) is a common aggressive malignancy with a low survival rate that lacks viable therapeutic options beyond mastectomy. Recently, increasing efforts have been made to understand the molecular mechanisms underlying FMC development, using the knowledge gained from studies on human breast cancer to discover new diagnostic and prognostic biomarkers, thus reinforcing the utili...
Diagnostic value of VEGF-A, VEGFR-1 and VEGFR-2 in Feline mammary carcinoma
Nascimento, Catarina; Gameiro, Andreia; Ferreira, João; Correia, Jorge; Ferreira, FernandoVascular endothelial growth factor (VEGF-A) plays an essential role in tumor-associated angiogenesis, exerting its biological activity by binding and activating membrane receptors, as vascular endothelial growth factor receptor 1 and 2 (VEGFR-1, VEGFR-2). In this study, serum VEGF-A, VEGFR-1, and VEGFR-2 levels were quantified in 50 cats with mammary carcinoma and 14 healthy controls. The expression of these mo...