6 documents found, page 1 of 1
An overview on immunogenic cell death in cancer biology and therapy
Rodrigues, Mosar Corrêa; Morais, José Athayde Vasconcelos; Ganassin, Rayane; Oliveira, Giulia Rosa Tavares; Costa, Fabiana ChagasImmunogenic cell death (ICD) is a modality of regulated cell death that is sufficient to promote an adaptive immune response against antigens of the dying cell in an immunocompetent host. An important characteristic of ICD is the release and exposure of damage-associated molecular patterns, which are potent endogenous immune adjuvants. As the induction of ICD can be achieved with conventional cytotoxic agents, ...
Solid lipid nanoparticles loaded with curcumin: Development and in vitro toxici...
Ganassin, Rayane; Da Silva, Victor Carlos Mello; Araujo, Victor Hugo Sousa; Tavares, Giulia Rosa; Da Silva, Patrícia Bento; Cáceres-Vélez, Paolin RocioMade available in DSpace on 2022-05-01T13:41:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-02-01; Aim: To develop a new curcumin carrier consisting of murumuru butter nanoparticles (SLN-Cs). Methods: A phase-inversion temperature method was used to produce SLN-Cs. The interaction of SLN-Cs with murine colon adenocarcinoma (CT26) cells in vitro was analyzed by confocal microscopy. Results: Stable SLN...
Desenvolvimento de nanopartículas lipídicas sólidas para carreamento de curcumi...
Ganassin, RayaneTese (Doutorado)—Universidade de Brasília, Instituto de Ciências Biológicas, Programa de Pós-Graduação em Nanociência e Nanobiotecnologia, 2020.; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).; A quimioterapia contra o câncer continua sendo um desafio devido aos mecanismos de resistência das células tumorais e à toxicidade dos fármacos anticâncer. Estudos clínicos sugerem que as respostas ...
The influence of NLC composition on curcumin loading under a physicochemical pe...
Sousa Araujo, Victor Hugo; Silva, Patricia Bento da; Szlachetka, Isis Oliveira; Silva, Sebastiao William da; Fonseca-Santos, BrunoMade available in DSpace on 2020-12-12T00:07:55Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-10-05; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); The use of (nanostructured lipid carries) NLC to disperse curcumin in aqueous media is widely found in literature. However, few studies systematically analyze the influence of the lipid matrix composition and the presence of curcumin o...
Nanocápsulas de selol com invólucro de poli(metil vinil-éter co-anidrido maléic...
Ganassin, RayaneDissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Biológicas, Programa de Pós-Graduação em Biologia Animal, 2016.; A doxorrubicina (DOX) tem se mostrado eficaz no tratamento de cânceres sólidos e hematológicos, mas a sua potencial cardiotoxicidade irreversível, limita o sucesso do tratamento, levando a um baixo índice terapêutico. O selol, mistura de selenitotriacilglicerídeos, mostrou ativ...
PVM/MA-shelled selol nanocapsules promote cell cycle arrest in A549 lung adenoc...
Souza, Ludmilla Regina de; Muehlmann, Luis Alexandre; Santos, Mayara Simonelly Costa dos; Ganassin, Rayane; Simón-Vázquez, RosanaBackground: Selol is an oily mixture of selenitetriacylglycerides that was obtained as a semi-synthetic compound containing selenite. Selol is effective against cancerous cells and less toxic to normal cells compared with inorganic forms of selenite. However, Selol’s hydrophobicity hinders its administration in vivo. Therefore, the present study aimed to produce a formulation of Selol nanocapsules (SPN) and to ...