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Conotoxin loaded dextran microgel particles alleviate effects of spinal cord in...

Zhao, X.; Jin, L.; Zhu, Z.; Lu, H.; Shi, H.; Zhong, Q.; Oliveira, J. M.; Reis, R. L.; Gao, C.; Zhengwei, M.

Spinal cord injury (SCI) is a severe refractory disabling condition accompanied by complicated patholog- ical processes, such as excessive glutamate release in the extracellular environment and massive influx of Ca 2 + into cells. Dextran can absorb extracellular glutamate and Ca 2 + to attenuate persistent excita- tory processes that are detrimental to normal cells. Calcium channel inhibitors reduce the influx...


Advanced biomaterials and processing methods for liver regeneration: state‐of‐t...

da Silva Morais, A.; Vieira, S.; Zhao, X.; Mao, Z.; Gao, C.; Oliveira, Joaquim M.; Reis, R. L.

Liver diseases contribute markedly to the global burden of mortality and disease. The limited organ disposal for orthotopic liver transplantation results in a continuing need for alternative strategies. Over the past years, important progress has been made in the field of tissue engineering (TE). Many of the early trials to improve the development of an engineered tissue construct are based on seeding cells ont...


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