4 documents found, page 1 of 1
Reinforced plant-derived lipid nanoparticles for oral precise epigenome editing...
Gao, Qiang; Gao, Yunxia; Cao, Yingui; Xu, Haiting; Ma, Ya; Zu, Menghang; Yang, Qiang; Yang, Kun; Zhu, Zhenhua; Liu, Chao; Shi, X. X.; Reis, R. L.The clinical application of CRISPR-Cas9 remains limited by delivery challenges, particularly for oral administration. Lysine-specific demethylase 1 (Lsd1) plays a key role in colonic inflammation and tumorigenesis. Here, we developed an oral genome-editing platform (TPGS-RNP@LNP), where Lsd1-targeting ribonucleoproteins (RNPs) were encapsulated in mulberry leaf lipid nanoparticles (LNPs) and formulated with d-α...
Oral exosome-like nanovesicles from Phellinus linteus suppress metastatic hepat...
Zu, Menghang; Liu, Ga; Chen, Nanxi; Chen, Li; Gao, Qiang; Reis, R. L.; Kundu, Subhas C; Jin, Meilan; Xiao, Bo; Shi, XiaoxiaoThe biomedical application of nanotechnology in cancer treatment has demonstrated significant potential for improving treatment efficiencies and ameliorating adverse effects. However, the medical translation of nanotechnology-based nanomedicines faces challenges including hazardous environmental effects, difficulties in large-scale production, and possible excessive costs. In the present study, we extracted and...
Mulberry leaf lipid nanoparticles: a naturally targeted CRISPR/Cas9 oral delive...
Ma, Lingli; Ma, Ya; Gao, Qiang; Liu, Shengsheng; Zhu, Zhenhua; Shi, Xiaoxiao; Dai, Fangyin; Reis, R. L.; Kundu, Subhas C; Cai, Kaiyong; Xiao, BoOral treatment of colon diseases with the CRISPR/Cas9 system has been hampered by the lack of a safe and efficient delivery platform. Overexpressed CD98 plays a crucial role in the progression of ulcerative colitis (UC) and colitis-associated colorectal cancer (CAC). In this study, lipid nanoparticles (LNPs) derived from mulberry leaves are functionalized with Pluronic copolymers and optimized to deliver the CR...
Natural lipid nanoparticles extracted from Morus nigra L. leaves for targeted t...
Gao, Qiang; Chen, Nanx; Li, Baoyi; Zu, Menghang; Ma, Ya; Xu, Haiting; Zhu, Zhenhua; Reis, R. L.; Kundu, Subhas C; Xiao, BoThe clinical application of conventional medications for hepatocellular carcinoma treatment has been severely restricted by their adverse effects and unsatisfactory therapeutic effectiveness. Inspired by the concept of â medicine food homologyâ , we extracted and purified natural exosome-like lipid nanoparticles (LNPs) from black mulberry (Morus nigra L.) leaves. The obtained MLNPs possessed a desirable hydrod...