3 documents found, page 1 of 1
Global, regional, and national burden of mortality associated with cold spells ...
Gao, Yuan; Huang, Wenzhong; Zhao, Qi; Ryti, Niilo; Armstrong, Ben; Gasparrini, Antonio; Tong, Shilu; Pascal, Mathilde; Urban, Aleš; Zeka, ArianaBackground: Exposure to cold spells is associated with mortality. However, little is known about the global mortality burden of cold spells. Methods: A three-stage meta-analytical method was used to estimate the global mortality burden associated with cold spells by means of a time series dataset of 1960 locations across 59 countries (or regions). First, we fitted the location-specific, cold spell-related morta...
Genome-wide association study heterogeneous cohort homogenization via subject w...
Valente, André X. C. N.; Zischkau, Joseph; Shin, Joo Heon; Gao, Yuan; Sarkar, AbhijitPopulation structure can be a source of both false-positive and false-negative findings in a genome-wide association study. This article proposes an approach that helps to reduce the false-positives. It consists of homogenizing the diseased/healthy phenotype ratio across the cohort, by decreasing the statistical weight of selected individuals. After homogenization, the cohort is statistically handled as if orig...
Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's d...
Valente, André X. C. N.; Shin, Joo H.; Sarkar, Abhijit; Gao, YuanAn association between a rare, coding, non-synonymous SNP variant in the gene DZIP1 and Parkinson's disease was found, based on an analysis of the existing NGRC genome-wide association study dataset. The statistical analysis utilized the hypothesis-rich, targeted search unbiased assessment approach, rather than the hypothesis-free, genome-wide agnostic search paradigm. The association of DZIP1 with Parkinson's ...