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Health Communication in Portugal: Current Challenges and Prospects
De Santiago, Isabel; Magano, Raquel; Nogueira, Paulo; Ascenção, Raquel; M., Azinhais Figueiras; A., Cardoso Baptista; Correia, João; Fernandes, Pedro B.Background: Health communication is a fundamental component of public health promotion and is crucial for disseminating information, raising public awareness of healthy behaviours and managing health crises. In Portugal, health communication has evolved over the last few decades, adapting to new technologies and the growing need for accurate and accessible information. However, there are still significant chall...
Behavioral phenotyping of Parkin-deficient mice: looking for early preclinical ...
Rial, Daniel; Castro, Adalberto A.; Machado, Nuno J.; Garção, Pedro; Gonçalves, Francisco Q.; Silva, Henrique B.; Tomé, Ângelo R.; Köfalvi, AttilaThere is considerable evidence showing that the neurodegenerative processes that lead to sporadic Parkinson's disease (PD) begin many years before the appearance of the characteristic motor symptoms. Neuropsychiatric, sensorial and cognitive deficits are recognized as early non-motor manifestations of PD, and are not attenuated by the current anti-parkinsonian therapy. Although loss-of-function mutations in the...
Functional interaction between presynaptic nicotinic and adenosine receptors in...
Garção, PedroTese de doutoramento do Programa de Doutoramento em Ciências da Saúde, no ramo de Ciências Biomédicas, apresentada à Faculdade de Medicina da Universidade de Coimbra; Os receptores colinérgicos nicotínicos (nAChRs) e os receptores A2A de adenosina (A2ARs) pré-sinápticos são moduladores importantes da libertação de neurotransmissores no estriado. Foi demonstrado que os A2ARs controlam a taxa de desensitização de...
Comparative study of microglia activation induced by amyloid-beta and prion pep...
Garção, Pedro; Oliveira, Catarina R.; Agostinho, PaulaThe inflammatory responses in Alzheimer's disease (AD) and prion-related encephalopathies (PRE) are dominated by microglia activation. Several studies have reported that the amyloid-beta (Abeta) peptides, which are associated with AD, and the pathogenic isoform of prion protein (PrPSc) have a crucial role in neuronal death and gliosis that occur in both of these disorders. In this study, we investigate whether ...