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Role of germline aberrations affecting CTNNA1, MAP3K6 and MYD88 in gastric canc...
Weren, R; Van, Der Post R; Vogelaar, I; Han, Van Krieken J; Spruijt, L; Lubinski, J; Jakubowska, A; Teodorczyk, U; Aalfs, C; Van, Hest L; Oliveira, CBackground In approximately 10% of all gastric cancer (GC) cases, a heritable cause is suspected. A subset of these cases have a causative germline CDH1 mutation; however, in most cases the cause remains unknown. Our objective was to assess to what extent these remaining cases may be explained by germline mutations in the novel candidate GC predisposing genes CTNNA1, MAP3K6 or MYD88. Methods We sequenced a larg...
Date: 2018
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Origin: Repositório Aberto da Universidade do Porto