15 documents found, page 1 of 2
Lipid nanoparticles for the posterior eye segment
Bonilla, Lorena; Espina, Marta; Severino, Patricia; Cano, Amanda; Ettcheto, Miren; Camins, Antoni; García, Maria Luisa; Souto, Eliana B.This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for pathologies affecting the posterior ocular segment. Eye anatomy and the most relevant diseases affecting the posterior segment will be summarized. Moreover, preparation methods and different types and subtypes of lipid nanoparticles wil...
Nanomedicine-based technologies and novel biomarkers for the diagnosis and trea...
Cano, Amanda; Turowski, Patric; Ettcheto, Miren; Duskey, Jason Thomas; Tosi, Giovanni; Sánchez-López, Elena; García, Maria Luisa; Camins, AntonioIncreasing life expectancy has led to an aging population, which has consequently increased the prevalence of dementia. Alzheimer's disease (AD), the most common form of dementia worldwide, is estimated to make up 50-80% of all cases. AD cases are expected to reach 131 million by 2050, and this increasing prevalence will critically burden economies and health systems in the next decades. There is currently no t...
State of the Art on Toxicological Mechanisms of Metal and Metal Oxide Nanoparti...
García-Torra, Victor; Cano, Amanda; Espina, Marta; Ettcheto, Miren; Camins, Antoni; Barroso, Emma; Vazquez-Carrera, Manel; García, Maria LuisaMetal nanoparticles have been extensively investigated for different types of pharmaceutical applications. However, their use has raised some concerns about their toxicity involving the increase of reactive oxygen species causing cellular apoptosis. Therefore, in this review we summarize the most relevant toxicity mechanisms of gold, silver, copper and copper oxide nanoparticles as well as production methods of...
Nanomedicine-based technologies and novel biomarkers for the diagnosis and trea...
Cano, Amanda; Turowski, Patric; Ettcheto, Miren; Duskey, Jason Thomas; Tosi, Giovanni; Sánchez-López, Elena; García, Maria Luisa; Camins, AntonioIncreasing life expectancy has led to an aging population, which has consequently increased the prevalence of dementia. Alzheimer's disease (AD), the most common form of dementia worldwide, is estimated to make up 50--80% of all cases. AD cases are expected to reach 131 million by 2050, and this increasing prevalence will critically burden economies and health systems in the next decades. There is currently no ...
Diabetic Retinopathy and Ocular Melanoma: How Far We Are?
Souto, Eliana B.; Campos, Joana R.; Ana, Raquel da; Fangueiro, Joana F.; Martins-Gomes, Carlos; Durazzo, Alessandra; Lucarini, MassimoDiabetic retinopathy causes vascular damage to retinal neurons, presenting characteristics of chronic inflammation. The development of new therapies capable of combating vision loss involves knowledge of inflammatory retinal changes. Studies in animal models and patients with diabetes have shown a high expression of the inflammatory molecules that are involved in the progression of diabetic retinopathy. Uveal m...
Dexibuprofen biodegradable nanoparticles: one step closer towards a better ocul...
Sánchez-López, Elena; Esteruelas, Gerard; Ortiz, Alba; Espina, Marta; Prat, Josefina; Muñoz, Montserrat; Cano, Amanda; Calpena, Ana CristinaOcular inflammation is one of the most prevalent diseases in ophthalmology, which can affect various parts of the eye or the surrounding tissues. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, are commonly used to treat ocular inflammation in the form of eye-drops. However, their bioavailability in ocular tissues is very low (less than 5%). Therefore, drug delivery systems such as biodegradab...
State-of-the-art polymeric nanoparticles as promising therapeutic tools against...
Cano, Amanda; Ettcheto, Miren; Espina, Marta; López-Machado, Ana; Cajal, Yolanda; Rabanal, Francesc; Sánchez-López, Elena; Camins, AntonioInfectious diseases kill over 17 million people a year, among which bacterial infections stand out. From all the bacterial infections, tuberculosis, diarrhoea, meningitis, pneumonia, sexual transmission diseases and nosocomial infections are the most severe bacterial infections, which affect millions of people worldwide. Moreover, the indiscriminate use of antibiotic drugs in the last decades has triggered an i...
Current advances in the development of novel polymeric nanoparticles for the tr...
Cano, Amanda; Sánchez-López, Elena; Ettcheto, Miren; López-Machado, Ana; Espina, Marta; Souto, Eliana B.; Galindo, Ruth; Camins, AntonioEffective intervention is essential to combat the coming epidemic of neurodegenerative (ND) diseases. Nanomedicine can overcome restrictions of CNS delivery imposed by the bloodbrain barrier, and thus be instrumental in preclinical discovery and therapeutic intervention of ND diseases. Polymeric nanoparticles (PNPs) have shown great potential and versatility to encapsulate several compounds simultaneously in co...
Epigallocatechin-3-gallate PEGylated poly(lactic-co-glycolic) acid nanoparticle...
Cano, Amanda; Ettcheto, Miren; Espina, Marta; Auladell, Carmen; Folch, Jaume; Kühne, Britta A; Barenys, Marta; Sánchez-López, Elena; Souto, Eliana B.Aim: To compare free and nanoparticle (NP)-encapsulated epigallocatechin-3-gallate (EGCG) for the treatment of Huntingtons disease (HD)-like symptoms in mice. Materials \& methods: EGCG was incorporated into PEGylated poly(lactic-co-glycolic) acid NPs with ascorbic acid (AA). HD-like striatal lesions and motor deficit were induced in mice by 3-nitropropionic acid-intoxication. EGCG and EGCG/AA NPs were co-admin...
Diabetic retinopathy and ocular melanoma: how far we are?
Souto, Eliana B.; Campos, Joana R.; Da Ana, Raquel; Fangueiro, Joana F.; Martins-Gomes, Carlos; Durazzo, Alessandra; Lucarini, MassimoDiabetic retinopathy causes vascular damage to retinal neurons, presenting characteristics of chronic inflammation. The development of new therapies capable of combating vision loss involves knowledge of inflammatory retinal changes. Studies in animal models and patients with diabetes have shown a high expression of the inflammatory molecules that are involved in the progression of diabetic retinopathy. Uveal m...