Background: Matrix metalloproteinases (MMPs) are zinc-dependent enzymes that regulate extracellular matrix degradation and remodelling. Among them, MMP-8 and MMP-9 are key mediators of inflammation, tissue remodelling, and wound healing. They have been implicated in both type 1 diabetes mellitus (T1DM) and periodontal disease (PD) [1]. The literature indicates a bidirectional association between T1DM and PD: ch...
Head and neck cancer (HNC) patients submitted to radical chemoradiotherapy (CRT) have to deal with various physical and psychosocial problems related to cancer and its treatment, which negatively affect functional capacity and health-related quality of life (HRQoL). Thus, the aim of this work was to analyse the impact of an exercise prehabilitation (EP) program on the functional capacity and HRQoL in HNC patien...
To assess the effects of a group class physical exercise program on health-related quality of life (HRQOL), physical fitness and activity, and safety in early breast cancer women after treatment, a double phase trial [16-week control phase (CP) followed by a 16-week intervention phase (IP)] was designed. Outcomes were evaluated at baseline (T1), 8 (T2) and 16 (T3) weeks (CP), and 24 (T4) and 32 (T5) weeks (IP)....
Introduction: Resistant hypertension is a problematic phenotype marked by the limited efficacy of available blood pressure-lowering treatments [1], such as antihypertensive medicines and kidney denervation [2-4]. Given its economic and health-related impact, it is a major medical and societal concern. Patients with resistant hypertension have a higher risk of myocardial infarction, stroke, heart failure, chroni...
In non-valvular-associated atrial fibrillation (AF), direct oral anticoagulants (DOAC) are as effective as vitamin K antagonists (VKA) for the prevention of acute ischemic stroke (AIS). DOAC are associated with decreased risk and severity of intracranial hemorrhage. It is unknown if different pre-admission anticoagulants impact the prognosis of AF related AIS (AF-AIS). We sought to analyze the literature to ass...
Introduction: Guidance for pregnant women has been particularly problematic since the beginning of the COVID-19 pandemic. The aim of this study was to describe the characteristics and outcomes of pregnant women with SARS-CoV-2 infection and their newborns.Material and Methods: Case review of clinical records of pregnant women with SARS-CoV-2 infection admitted for delivery and their newborns from April to Decem...
Introdução: As Hemoglobinopatias são doenças genéticas, causadas por alterações da produção de hemoglobina, das quais se destacam a doença falciforme e os síndromes talassémicos. O diagnóstico precoce das hemoglobinopatias é essencial: permite a implementação de medidas que reduzem a morbilidade e a mortalidade nestes doentes (como a profilaxia antibiótica, a imunização alargada e a educação parental). Objeti...
A segurança dos doentes é reconhecida como um dos pilares fundamentais da qualidade dos cuidados de saúde, sendo prioritário desenvolver uma cultura de segurança que vise minimizar a ocorrência de erros e favorecendo a aprendizagem com os mesmos. Caracterizar a cultura de segurança da criança hospitalizada, percecionada pelos enfermeiros. Estudo quantitativo, descritivo-correlacional e transversal, efetuado num...
The Underwater Archaeological Parks (UAP) of the Azores are a cultural heritage protection initiative and an opportunity to promote fruition between archaeological sites and biodiversity. Respecting UNESCO’s “Convention on the Protection of the Underwater Cultural Heritage” principles, the UAPs were classified for the first time in 2005 and are unique in the Portuguese context. Due to the autonomy that this ult...
Objective: This article comprises a sample of abuse modalities observed in a pediatric emergency room of a public hospital in the Lisbon metropolitan area and a multifactorial characterization of physical and sexual violence. The objectives are: (1) to discuss the importance of social and family variables in the configuration of both types of violence; (2) to show how physical and sexual violence have subtypes ...