4 documents found, page 1 of 1
The adaptive immune landscape of the colorectal adenoma–carcinoma sequence
Freitas, JA; Gullo, I; Garcia, D; Miranda, S; Spaans, L; Pinho, L; Reis, J; Sousa, F; Baptista, M; Resende, C; Leitão, D; Durães, C; Costa, JLBackground. The tumor immune microenvironment exerts a pivotal influence in tumor initiation and progression. The aim of this study was to analyze the immune context of sporadic and familial adenomatous polyposis (FAP) lesions along the colorectal adenoma–carcinoma sequence (ACS). Methods. We analyzed immune cell counts (CD3+, CD4+, CD8+, Foxp3+, and CD57+), tumor mutation burden (TMB), MHC-I expression and PD-...
The influence of the genetic and immunologic context in the development of colo...
Garcia, D; Spaans, L; Miranda, S; Gonçalves, G; Reis, J; Costa, JL; Durães, C; Carneiro, F; Machado, JCIntroduction: Overcoming immunosurveillance is a major step in the progression of many types of tumors. Several immune escape strategies have been identified, including immunoediting and the establishment of an immune suppressive microenvironment. The aim of the present study was to determine whether the hereditary or sporadic context has any influence in the relationship between immune surveillance and tumor d...
Comparison of a rapid test and an automated method for faecal calprotectin meas...
Martins, S; Garcia, D; Farinha, R; Guimarães, JTn/a
Renin, aldosterone, urinary sodium and weight change in cirrhotic patients with...
Rocha, M P; Gorjão, R; Garcia, D; Siqueira, C; Faro, L; Pinto Correia, J