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Using artificial intelligence to prioritize pathology samples: report of a test...
Rienda, Iván; Vale, João; Pinto, João; Polónia, António; Eloy, CatarinaThe digital transformation of pathology, through automation and computational tools, addresses current challenges in the field. This study evaluates Paige Pan Cancer, a novel artificial intelligence tool based on the Virchow foundation model, designed to flag invasive cancer in haematoxylin and eosin-stained slides from 16 primary tissue types. Using 62 cases from the Ipatimup Pathology Laboratory, we found the...
Optimizing the management of thyroid specimens to efficiently generate whole sl...
Eloy, Catarina; Vale, João; Barros, Mariana; Oliveira, Diana; Mesquita, Morgana; Curado, Mónica; Pinto, João; Polónia, AntónioTransition from optical to digital observation requires an additional procedure in the pathology laboratory, the scanning of glass slides, leading to increased time and digital archive consumption. Thyroid surgical samples often carry the need to collect several tissue fragments that generate many slides to be scanned. This study evaluated the impact of using different inking colours for the surgical margin, se...
Inking cell blocks improves scanner detection for diagnosis in pathology
Eloy, Catarina; Neves, Beatriz; Vale, João; Campelos, Sofia; Curado, Mónica; Polónia, AntónioCell blocks may be hard to be totally automatically detected by the scanner (ADS),generating incomplete whole slide images (WSIs), with areas that are not scanned,leading to possible false negative diagnosis. The aim of this study is to test if inkingthe cell blocks helps increasing ADS. Test 1: 15 cell blocks were sectioned, one halfinked black (1HB) and the other inked green (1HG). Each of the halves was indi...
NIS expression in thyroid tumors, relation with prognosis clinicopathological a...
Tavares, Catarina; Coelho, Maria João; Eloy, Catarina; Melo, Miguel; da Rocha, Adriana Gaspar; Pestana, Ana; Batista, Rui; Ferreira, Luciana BuenoThyroid cancer therapy is based on surgery followed by radioiodine treatment. The incorporation of radioiodine by cancer cells is mediated by sodium iodide symporter (NIS) (codified by the SLC5A5 gene), that is functional only when targeted to the cell membrane. We aimed to evaluate if NIS expression in thyroid primary tumors would be helpful in predicting tumor behavior, response to therapy and prognosis. NIS ...
mTOR Pathway in Papillary Thyroid Carcinoma: Different Contributions of mTORC1 ...
Tavares, Catarina; Eloy, Catarina; Melo, Miguel; Gaspar da Rocha, Adriana; Pestana, Ana; Batista, Rui; Bueno Ferreira, Luciana; Rios, ElisabeteThe mammalian target of rapamycin (mTOR) pathway is overactivated in thyroid cancer (TC). We previously demonstrated that phospho-mTOR expression is associated with tumor aggressiveness, therapy resistance, and lower mRNA expression of SLC5A5 in papillary thyroid carcinoma (PTC), while phospho-S6 (mTORC1 effector) expression was associated with less aggressive clinicopathological features. The distinct behavior...
CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid carcinoma, and ...
Celestino, Ricardo; Nome, Torfinn; Pestana, Ana; Hoff, Andreas M.; Gonçalves, A. Pedro; Pereira, Luísa; Cavadas, Bruno; Eloy, Catarina; Bjøro, TrineBackground: The prognostic variability of thyroid carcinomas has led to the search for accurate biomarkers at the molecular level. Follicular thyroid carcinoma (FTC) is a typical example of differentiated thyroid carcinomas (DTC) in which challenges are faced in the differential diagnosis. Methods: We used high-throughput paired-end RNA sequencing technology to study four cases of FTC with different degree of c...
Fine-needle Aspiration of Thyroid Nodules: Is it Worth Repeating?
Fernandes, Vera; Pereira, Tânia; Eloy, CatarinaIntroduction: The fine-needle aspiration has a significant role in assessing the malignancy risk of thyroid nodules. There is uncertainty regarding the value of repeat fine-needle aspiration in benign nodules. This study aims to evaluate the concordance of results in consecutive fine-needle aspiration and to study the relevance of repetition in benign results.Material and Methods: Retrospective study of the 480...
TERT promoter mutations are a major indicator of poor outcome in differentiated...
Melo, Miguel; Gaspar Da Rocha, Adriana; Vinagre, João; Batista, Rui; Peixoto, Joana; Tavares, Catarina; Celestino, Ricardo; Almeida, AnaContext: Telomerase promoter mutations (TERT) were recently described in follicular cell-derived thyroid carcinomas (FCDTC) and seem to be more prevalent in aggressive cancers. Objectives: We aimed to evaluate the frequency of TERT promoter mutations in thyroid lesions and to investigate the prognostic significance of such mutations in a large cohort of patients with differentiated thyroid carcinomas (DTCs). De...
PROLIDASE DEFICIENCY – A RARE CAUSE OF LEG ULCERS IN PEDIATRIC AGE
Cruz, Maria João; Mota, Alberto; Baudrier, Teresa; Silva, Elisa; Eloy, Catarina; Azevedo, FilomenaProlidase deficiency is a rare, autosomal recessive disease resulting from a mutation of the prolidase gene (PEPD) located on chromosome 19. The deficiency of this enzyme impairs proline recycling and consequently the synthesis of collagen. This defect may be asymptomatic or associated with different clinical manifestations, being the most frequently reported chronic skin ulcers, recurrent infections, hepatospl...
Genetic alterations in poorly differentiated and undifferentiated thyroid carci...
Soares, Paula; Lima, Jorge; Almeida, Ana; Castro, Patrícia; Vinagre, João; Celstino, Ricardo; Couto, Joana Pinto; Prazeres, Hugo; Eloy, CatarinaThyroid gland presents a wide spectrum of tumours derived from follicular cells that range from well differentiated, papillary and follicular carcinoma (PTC and FTC, respectively), usually carrying a good prognosis, to the clinically aggressive, poorly differentiated (PDTC) and undifferentiated thyroid carcinoma (UTC). It is usually accepted that PDTC and UTC occur either de novo or progress from a pre-existing...