4 documents found, page 1 of 1
Hoxb7 overexpression leads triple-negative breast cancer cells to a less aggres...
Garcia, SAB; Araújo, M; Pereira, T; Freitas, RHOX genes appear to play a role in breast cancer progression in a molecular subtype-dependent way. The altered expression of HOXB7, for example, was reported to promote breast cancer progression in specific subtypes. Here we induced HOXB7 overexpression in MDA-MB-231 cells, a cellular model of the Triple-Negative breast cancer molecular subtype, and evaluated the phenotypic changes in cell viability, morphogene...
Roles of the hox proteins in cancer invasion and metastasis
Paço, A; Garcia, SAB; Leitão-Castro, J; Costa-Pinto, AR; Freitas, RInvasion and metastasis correspond to the foremost cause of cancer-related death, and the molecular networks behind these two processes are extremely complex and dependent on the intra-and extracellular conditions along with the prime of the premetastatic niche. Currently, several studies suggest an association between the levels of HOX genes expression and cancer cell invasion and metastasis, which favour the ...
Methylation in HOX Clusters and Its Applications in Cancer Therapy
Paço, A; Garcia, SAB; Freitas, RHOX genes are commonly known for their role in embryonic development, defining the positional identity of most structures along the anterior-posterior axis. In postembryonic life, HOX gene aberrant expression can affect several processes involved in tumorigenesis such as proliferation, apoptosis, migration and invasion. Epigenetic modifications are implicated in gene expression deregulation, and it is accepted ...
Dataset of HOXB7, HOXB8 and HOXB9 expression profiles in cell lines representat...
Garcia, SAB; Araújo, M; Freitas, RAlterations in HOXB genes expression in breast cancer have been described and related to therapy response and disease progression. However, due to breast cancer complexity and heterogeneity, added to the use of different technical approaches, the observed expression profiles are sometimes contradictory. Here, we provided the analyses of HOXB7, HOXB8 and HOXB9 expression profiles in cell lines extensively used i...