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Soft culture substrates favor stem-like cellular phenotype and facilitate repro...
Gerardo, Heloísa; Lima, Ana; Carvalho, João; Ramos, João R. D.; Couceiro, Sofia; Travasso, Rui D.; Neves, Ricardo Pires das; Grãos, MárioBiophysical cues influence many aspects of cell behavior. Stiffness of the extracellular matrix is probed by cells and transduced into biochemical signals through mechanotransduction protein networks, strongly influencing stem cell behavior. Cellular stemness is intimately related with mechanical properties of the cell, like intracellular contractility and stiffness, which in turn are influenced by the microenv...
Date: 2019
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Origin: Estudo Geral - Universidade de Coimbra