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Dual Effect of Nitrate Therapy for Cyclosporine-Induced Hypertension on Vascula...
Reis, F.; Lemos, E. Teixeira de; Almeida, L.; Parada, B.; Garrido, A. P.; Rocha-Pereira, P.; Santos-Silva, A.; Santos-Dias, J.; Dinis, A.The present study sought to evaluate the prevention and reversion effects of isosorbide-5-mononitrate (Is-5-Mn) on the development of hypertension (HT) and on the underlying vascular and platelet morphofunctional disturbances, using an animal model of cyclosporine (CsA)-induced HT. The following rat groups (n = 8) were tested: (1) a control group (orange juice, for 7 weeks); (2) the CsA group (5 mg/kg/d for 7 w...
Date: 2007
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Origin: Estudo Geral - Universidade de Coimbra