8 documents found, page 1 of 1
The Percentage of [−2]Pro–Prostate-Specific Antigen and the Prostate Health Ind...
Garrido, MM; Marta, JC; Bernardino, RM; Guerra, J; Fernandes, F; Pereira, MH; Ribeiro, R; Holdenrieder, S; Pinheiro, LC; Guimarães, JTContext.—: There is a need to avoid the overdiagnosis of prostate cancer (PCa) and to find more specific biomarkers. Objective.—: To evaluate the clinical utility of [-2]pro-prostate-specific antigen ([-2]proPSA) derivatives in detecting clinically significant PCa (csPCa) and to compare it with prostate-specific antigen (PSA) and with the percentage of free PSA (%fPSA). Design.—: Two hundred thirty-seven men (P...
The Percentage of [-2]Pro-Prostate-Specific Antigen and the Prostate Health Ind...
Garrido, MM; Marta, JC; Bernardino, RM; Guerra, J; Fernandes, F; Pereira, MH; Ribeiro, R; Holdenrieder, S; Pinheiro, LC; Guimarães, JTContext.— There is a need to avoid the overdiagnosis of prostate cancer (PCa) and to find more specific biomarkers. Objective.— To evaluate the clinical utility of [−2]pro–prostate-specific antigen ([−2]proPSA) derivatives in detecting clinically significant PCa (csPCa) and to compare it with prostate-specific antigen (PSA) and with the percentage of free PSA (%fPSA). Design.— Two hundred thirty-seven men (PSA:...
The prostate health index (PHI) density: Are there advantages over PHI or over ...
Garrido, MM; Ribeiro, RM; Pinheiro, LC; Holdenrieder, S; Guimarães, JTBackground and aims Overdiagnosis of prostate cancer (PCa) should be minimized. We wanted to evaluate the diagnostic performance of the prostate health index density (PHID) and compare it with that of the prostate health index (PHI) alone and of the prostate-specific antigen density (PSAD). Materials and methods 232 men scheduled for a prostate biopsy (prostate-specific antigen level: 2–10 µg/L), were enrolled....
Comparison of Three Assays for Total and Free PSA Using Hybritech and WHO Calib...
Garrido, MM; Marta, JC; Ribeiro, RM; Pinheiro, LC; Holdenrieder, S; Guimarães, JTBackground/Aim: Lack of interchangeability between prostate-specific antigen (PSA) assays could have a clinical impact. We compared PSA assays from different manufacturers and calibrations. Patients and Methods: A total of 233 men who underwent prostate biopsy (PSA: 2-10 ng/ml; Beckman Coulter Access® Hybritech® as reference) were enrolled. Total (tPSA) and free PSA (fPSA) were also measured using the Roche cob...
Tumour markers in prostate cancer: The post-prostate-specific antigen era
Garrido, MM; Bernardino, RM; Marta, JC; Holdenrieder, S; Guimarães, JTAlthough prostate-specific antigen-based prostate cancer screening had a positive impact in reducing prostate cancer mortality, it also led to overdiagnosis, overtreatment and a significant number of unnecessary biopsies. In the post-prostate-specific antigen era, new biomarkers have emerged that can complement the information given by prostate-specific antigen, towards a better cancer diagnostic specificity, a...
The prostate health index and the percentage of [-2]proPSA maintain their diagn...
Garrido, MM; Ribeiro, R; Pinheiro, LC; Holdenrieder, S; Guimarães, JTObjectives To evaluate the diagnostic performance of the prostate health index (PHI) and of the percentage of [-2]proPSA (%[-2]proPSA) calculated with total and free PSA from non-Beckman Coulter manufacturers (Roche and Abbott), and compare it with the fully Beckman Coulter [-2]proPSA derivatives. Methods In this study, 237 men (PSA: 2–10 μg/L) scheduled for prostate biopsy were enrolled. %[-2]proPSA and PHI we...
Are Proinflammatory Cytokines Relevant for the Diagnosis of Prostate Cancer?
Garrido, MM; Ribeiro, RM; Krüger, K; Pinheiro, LC; Guimarães, JT; Holdenrieder, S"Background/aim: Inflammation plays an important role in prostate cancer (PCa). We evaluated proinflammatory cytokines regarding differential diagnosis of PCa in men with PSA levels between 2-10 ng/ml. Patients and methods: Serum samples of 79 men (PSA 2-10 ng/ml) were analyzed for 10 proinflammatory cytokines (IL-6, IL-8, TNF-α, IFN-γ, IL-10, IL-1β, IL-2, IL-4, IL-12p70, IL-13) and results were evaluated regar...
Relevance of Circulating Nucleosomes, HMGB1 and sRAGE for Prostate Cancer Diagn...
Garrido, MM; Ribeiro, RM; Krüger, K; Pinheiro, LC; Guimarães, JT; Holdenrieder, SBackground/Aim: Evasion from cell death occurs in prostate cancer (PCa). We verified whether serum levels of cell death markers can have diagnostic value in PCa. Patients and Methods: A total of 233 men scheduled for prostate biopsy [prostate specific antigen (PSA) level: 2-10 ng/ml] were enrolled. Serum nucleosomes, nucleosomes containing the H3 histone (H3), high mobility group box 1 (HMGB1), and soluble rece...