15 documents found, page 1 of 2
Insights into Grapevine Defence Response Against Fungal and Oomycete Diseases T...
Patanita, Mariana; Félix, Maria do Rosário; Ribeiro, Joana A.; Varanda, Carla; Albuquerque, André; Materatski, Patrick; Garrido, NicolásDowny mildew, powdery mildew, grey mould, black rot, and grapevine trunk diseases are among the most important fungal or oomycete diseases affecting grapevine, with a high economic impact in all growing areas. In recent decades, extensive efforts have been made to reduce the use of agrochemicals in viticulture, turning the management of these diseases a major challenge. Given the urgent need to identify and dev...
Changes in environmental exposures over decades may influence the genetic archi...
Cerván-Martín, Miriam; González-Muñoz, Sara; Guzmán-Jiménez, Andrea; Higueras-Serrano, Inmaculada; Castilla, José A.; Garrido, Nicolás; Luján, SaturninoStudy question: Do the genetic determinants of idiopathic severe spermatogenic failure (SPGF) differ between generations? Summary answer: Our data support that the genetic component of idiopathic SPGF is impacted by dynamic changes in environmental exposures over decades. What is known already: The idiopathic form of SPGF has a multifactorial etiology wherein an interaction between genetic, epigenetic, and envi...
Papel da proteína de planta Dicer-like 4 nas infeções mistas dos vírus OMMV e O...
Varanda, Carla; Castanho, Beatriz; Albuquerque, André; Ribeiro, Joana; Patanita, Mariana; Garrido, Nicolás; Campos, Maria DoroteiaOs vírus Olive mild mosaic virus (OMMV) e Olive latent virus 1 (OLV-1) estão largamente disseminados nos olivais portugueses, aparecendo frequentemente em infeções mistas. Estudos anteriores realizados em plantas de Nicotiana benthamiana, revelaram que quando os vírus estão presentes em infeções mistas, observa-se uma intensificação dos sintomas, sugerindo um efeito sinérgico. Neste trabalho, pretendeu-se testa...
Outdoor Finishing of Intact Male Portuguese Alentejano Pigs on a Sustainable Hi...
Martins, José Manuel; Varino, Ricardo; Charneca, Rui; Albuquerque, André; Garrido, Nicolás; Neves, José; Freitas, Amadeu; Costa, Filipa; Marmelo, CarlaThis trial evaluated the effect of sex on the blood, growth, carcass, meat quality, and boar taint compounds in male Alentejano (AL) pigs (n = 30). From ~40 to 130 kg LW, castrated (C) and intact pigs (I and IExp groups) were fed commercial diets ad libitum. Between ~130 and 160 kg (slaughter), C and I pigs continued on commercial diets, while IExp were fed an experimental diet containing locally produced pulse...
Transcriptomic Profiling of Subcutaneous Backfat in Castrated and Intact Alente...
Garrido, Nicolás; Albuquerque, André; Charneca, Rui; Costa, Filipa; Marmelo, Carla; Ramos, Amélia; Martin, Luísa; Martins, José ManuelIn this work, we studied the backfat transcriptome of surgically castrated (C), intact (I) and intact fed an experimental diet (IE) outdoor-reared male Alentejano (AL) pigs. The experimental diet was a high-fiber diet with locally produced legumes and by-products associated with a boar taint reduction effect. At slaughter (~160 kg), backfat samples were collected for total RNA sequencing. Intact pigs presented ...
Influence of Sex on Meat and Fat Quality from Heavy Alentejano Pigs Finished Ou...
Martins, José Manuel; Charneca, Rui; Garrido, Nicolás; Albuquerque, André; Jerónimo, Eliana; Guerreiro, Olinda; Lage, Patrícia; Marmelo, CarlaThis work aimed to examine the effects of sex on meat and fat quality traits from thirty Portuguese Alentejano (AL) pigs reared in outdoor conditions. These pigs were divided into three groups and fed ad libitum. From ~40 to 130 kg LW, castrated (C group) and intact animals (I and IExp) consumed commercial diets. Until slaughter (~160 kg), C and I pigs remained on commercial diets, and IExp changed to a more su...
Contribution of TEX15 genetic variants to the risk of developing severe non-obs...
Guzmán-Jiménez, Andrea; González-Muñoz, Sara; Cerván-Martín, Miriam; Rivera-Egea, Rocío; Garrido, Nicolás; Luján, Saturnino; Santos-Ribeiro, SamuelBackground: Severe spermatogenic failure (SPGF) represents one of the most relevant causes of male infertility. This pathological condition can lead to extreme abnormalities in the seminal sperm count, such as severe oligozoospermia (SO) or non-obstructive azoospermia (NOA). Most cases of SPGF have an unknown aetiology, and it is known that this idiopathic form of male infertility represents a complex condition...
Common Variation in the PIN1 Locus Increases the Genetic Risk to Suffer from Se...
Cerván-Martín, Miriam; Bossini-Castillo, Lara; Guzmán-Jimenez, Andrea; Rivera-Egea, Rocío; Garrido, Nicolás; Luján, Saturnino; Romeu, GemaWe aimed to analyze the role of the common genetic variants located in the PIN1 locus, a relevant prolyl isomerase required to control the proliferation of spermatogonial stem cells and the integrity of the blood-testis barrier, in the genetic risk of developing male infertility due to a severe spermatogenic failure (SPGF). Genotyping was performed using TaqMan genotyping assays for three PIN1 taggers (rs228783...
Common genetic variation in KATNAL1 non-coding regions is involved in the susce...
Cerván‐Martín, Miriam; Bossini‐Castillo, Lara; Guzmán‐Jiménez, Andrea; Rivera‐Egea, Rocío; Garrido, Nicolás; Lujan, Saturnino; Romeu, GemaBackground: Previous studies in animal models evidenced that genetic mutations of KATNAL1, resulting in dysfunction of its encoded protein, lead to male infertility through disruption of microtubule remodelling and premature germ cell exfoliation. Subsequent studies in humans also suggested a possible role of KATNAL1 single nucleotide polymorphisms in the development of male infertility as a consequence of seve...
Immune and spermatogenesis-related loci are involved in the development of extr...
Cerván-Martín, Miriam; Tüttelmann, Frank; Lopes, Alexandra M.; Bossini-Castillo, Lara; Rivera-Egea, Rocío; Garrido, Nicolás; Lujan, SaturninoWe conducted a genome-wide association study in a large population of infertile men due to unexplained spermatogenic failure (SPGF). More than seven million genetic variants were analysed in 1,274 SPGF cases and 1,951 unaffected controls from two independent European cohorts. Two genomic regions were associated with the most severe histological pattern of SPGF, defined by Sertoli cell-only (SCO) phenotype, name...