5 documents found, page 1 of 1
Correction: The meaning of lymphadenopathies during adjuvant durvalumab after c...
Pantarotto, Marcos; Barata, Rita; Coelho, Ricardo; Sousa, Virginia; Carvalheiro, Catarina; Rolim, Ines; Garrido, Patricia; GIl, NunoThis article has been corrected at the request of the authors to include Virginia Sousa as the fourth author as she was erroneously omitted during the submission process. The authors deeply regret that this error was not identified and addressed prior to publication.
The meaning of lymphadenopathies during adjuvant durvalumab after chemoradiothe...
Pantarotto, Marcos; Barata, Rita; Coelho, Ricardo; Carvalheiro, Catarina; Rolim, Ines; Garrido, Patricia; GIl, Nuno; Duarte-Ramos, FilipaImmune-checkpoint inhibitors (ICIs) have become the mainstay of treatment for many malignancies. With this new strategy, relevant immune-related adverse events (irAEs) have been reported, some of which can be mistaken for disease progression. To better illustrate the current challenges in diagnosing and managing a patient under adjuvant ICI treatment, we present the case of a 67-year-old female patient with sta...
Inhibition of bladder tumor growth by chitooligosaccharides in an experimental ...
Fernandes, João C.; Sereno, José; Garrido, Patricia; Parada, Belmiro; Cunha, Maria F. X.; Reis, Flávio; Pintado, Manuela E.; Santos-Silva, AliceUrinary bladder cancer is one of the most common cancers worldwide, with the highest incidence in industrialized countries. Patients with cancer commonly use unconventional and complementary therapy including nutraceuticals. In this study we evaluated the efficacy of chitooligosaccharides (in orange juice) in rat bladder cancer chemoprevention and as therapeutic agent, on a rat model of urinary bladder carcinog...
Anti-inflammatory, anti-proliferative and antioxidant profiles of selective cyc...
Parada, Belmiro; Sereno, Jose; Reis, Flavio; Teixeira-Lemos, Edite; Garrido, Patricia; Pinto, Angela Filipa; Cunha, Maria Fernanda; Pinto, RuiPurpose: To evaluate the efficacy of a selective cyclooxygenase-2 (COX-2) inhibitor in rat bladder cancer chemoprevention, as well as to assess the relevance of inflammation, proliferation and oxidative stress in tumor growth and in its prevention. Results: The main findings were: (I) the incidence of carcinoma was: control: 0% (0/8); BBN: 65% (13/20); CEL: 0% (0/8) and BBN + CEL: 12.5% (1/8); (II) the mean tum...
Erythropoietin Promotes Deleterious Cardiovascular Effects and Mortality Risk i...
Piloto, Nuno; Teixeira, Helena M.; Teixeira-Lemos, Edite; Parada, Belmiro; Garrido, Patricia; Sereno, Jose; Pinto, Rui; Carvalho, Lina; Costa, ElisioAthletes who abuse recombinant human erythropoietin (rhEPO) consider only the benefit to performance and usually ignore the potential short and long-term liabilities. Elevated haematocrit and dehydratation associated with intense exercise may reveal undetected cardiovascular risk, but the mechanisms underlying it remain to be fully explained. This study aimed to evaluate the cardiovascular effects of rhEPO in r...