8 documents found, page 1 of 1
Clinically relevant multidrug resistant Salmonella enterica in swine and meat h...
Neves, Eduarda; Antunes, Patrícia; Manageiro, Vera; Gartner, Fátima; Caniça, Manuela; Costa, José; Peixe, LuisaThe presence of multidrug resistant (MDR) Salmonella serotypes in slaughtered swine, carcasses, meat and meat handlers is scarcely evaluated. Recently we demonstrated that diverse Salmonella serotypes are frequently present in swine, pork meat and carcasses, and meat handlers at Portuguese abattoirs. Here we have characterized their antibiotic resistance phenotypes and genotypes, helping elucidate the flow of M...
ERBB2 in Cat Mammary Neoplasias Disclosed a Positive Correlation between RNA an...
Santos, Sara; Batista, Claudia S.; Abreu, Rui M.V.; Bastos, Estela; Amorim, Irina; Gut, Ivo G.; Gartner, Fátima; Chaves, RaquelHuman ERBB2 is a proto-oncogene that codes for the erbB-2 epithelial growth factor receptor. In human breast cancer (HBC), erbB-2 protein overexpression has been repeatedly correlated with poor prognosis. In more recent works, underexpression of this gene has been described in HBC. Moreover, it is also recognised that oncogenes that are commonly amplified or deleted encompass point mutations, and some of these ...
Studies on the biocompatibility of bacterial cellulose.
Alexandre, Nuno; Andrade, Fábia; Amorim, Irina; Gartner, Fátima; Maurício, Ana Colette; Luís, Ana Lúcia; Gama, MiguelBacterial cellulose was functionalized with a chimeric protein containing a cellulose-binding module and the adhesion peptide Arg-Gly-Asp. Small-diameter bacterial cellulose membranes were produced and subcutaneously implanted in sheep for 1–32 weeks. The implants triggered a biological response similar to other high surface-to-volume implants. There were no significant differences in the inflammation degree be...
Studies on the biocompatibility of bacterial cellulose
Andrade, Fábia K.; Alexandre, Nuno; Amorim, Irina; Gartner, Fátima; Maurício, Ana Colette; Luís, Ana Lúcia; Gama, MiguelBacterial cellulose was functionalized with a chimeric protein containing a cellulose-binding module and the adhesion peptide Arg-Gly-Asp. Small-diameter bacterial cellulose membranes were produced and subcutaneously implanted in sheep for 1–32 weeks. The implants triggered a biological response similar to other high surface-to-volume implants. There were no significant differences in the inflammation degree be...
Bacterial cellulose: long-term biocompatibility studies
Pértile, Renata Aparecida Nedel; Moreira, Susana Margarida Gomes; Costa, Rui M. Gil da; Correia, Alexandra; Guardão, Luísa; Gartner, FátimaThe bacterial cellulose (BC) secreted by G. xylinus is a network of pure cellulose nanofibers, which has high crystallinity, wettability and mechanical strength. These characteristics make BC an excellent material for tissue engineering constructs, noteworthy for artificial vascular grafts. In this work, the in vivo biocompatibility of BC membranes produced by two G. xylinus strains was analyzed through histolo...
In vivo biocompatibility and biodegradability of dextrin-based hydrogels
Moreira, Susana Margarida Gomes; Costa, Rui M. Gil da; Guardão, Luísa; Gartner, Fátima; Vilanova, Manuel; Gama, F. M.The in vivo biocompatibility of dextrin hydrogels obtained by polymerization of dextrin-hydroxyethylmethacrylate (dextrin-HEMA) and dextrin-vinyl acrylate (dextrin-VA) are reported in this work. The histological analysis of subcutaneous implants of these hydrogels, featuring inflammatory and reabsorption events, were carried out over a 16-week period in mice. The dextrin-HEMA hydrogel was quickly and completely...
Xanthohumol inflammatory factor production and angiogenesis are inhibited by xa...
Monteiro, Rosário; Calhau, Conceição; Costa, Artur; Silva, Sandra Pinheiro; Guerreiro, Susana; Gartner, Fátima; Azevedo, Isabel; Soares, RaquelXanthohumol (XN), a natural polyphenol present in beer, is known to exert anti-cancer effects. However, its precise mechanisms are not yet clearly defined. The aim of this study was to investigate the effect of oral administration of XN in breast cancer xenografts in nude mice. Proliferation and apoptosis were first examined in MCF7 cell cultures after incubation with XN by trypan blue exclusion assay, [3H]-thy...
Distribution of p63, cytokeratins 5/6 and cytokeratin 14 in 51 normal and 400 n...
Reis Filho, Jorge S.; Simpson, Pete T.; Martins, Albino; Preto, Ana; Gartner, Fátima; Schmitt, Fernando C.p63, cytokeratin (CK) 5/6 and CK 14 have been employed in diagnostic pathology as markers of basal, squamous and myoepithelial differentiation in several types of human neoplasms; however, there is scant data on the concurrent expression of these markers in large series of human neoplasms. We analyzed the distribution of these three immunohistochemical markers in 51 normal human tissue samples, 350 carcinomas, ...